Ali Gholami1,2,3, Farhad Zamani4, Bayan Hosseini5, Rahim Sharafkhani6, Mansooreh Maadi4, Zahra Moosavi Jahromi7,8, Maryam Khazaee-Pool9, Masoudreza Sohrabi4. 1. Department of Public Health, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran. 2. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. 3. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran. 4. Gastrointestinal and Liver Disease Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. 5. Department of Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. 6. PhD in Epidemiology, Khoy University of Medical Sciences, Khoy, Iran. 7. Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran. 8. School of Public Health, Zabol University of Medical Sciences, Zabol, Iran. 9. Department of Health Education and Promotion, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
Abstract
OBJECTIVE: This study was designed to examine the effect of metabolic syndrome (MetS) on health-related quality of life (HRQOL) in patients with suspected nonalcoholic steatohepatitis (NASH). SUBJECTS AND METHODS: Three hundred thirty-two patients (236 males and 96 females) with suspected NASH from the Amol cohort study were included in this study. MetS was diagnosed based on Adult Treatment Panel III criteria and HRQOL was measured using the 12-Item Short-Form Health Survey (SF-12) questionnaire (with 8 subscales and 2 summary components). A multivariable linear regression model was used to assess the independent effect of MetS on HRQOL. RESULTS: The mean age of the study population was 42 ± 13 years (range 18-82). The prevalence of MetS was 43.4% (n = 144) and the mean scores on the Physical Component Summary (PCS) and the Mental Component Summary were 72.4 ± 20.86 and 42.7 ± 12.42, respectively. The multivariable linear regression model showed that MetS was negatively associated with 4 subscales of HRQOL that included: role limitations due to physical problems (RP) (B = -14.05, p = 0.004), bodily pain (BP) (B = -7.37, p = 0.02), vitality (VT) (B = -7.72, p = 0.022), and role limitations due to emotional problems (RE) (B = -12.67, p = 0.005) after adjustment for other variables. Also, MetS had a borderline association with the general health and mental health subscales and the PCS (p < 0.1). CONCLUSION: In this study, there was a strong association between MetS and 4 subscales (RP, BP, VT, and RE) of HRQOL in patients with suspected NASH; this could be considered as a part of health policy to improve general health.
OBJECTIVE: This study was designed to examine the effect of metabolic syndrome (MetS) on health-related quality of life (HRQOL) in patients with suspected nonalcoholic steatohepatitis (NASH). SUBJECTS AND METHODS: Three hundred thirty-two patients (236 males and 96 females) with suspected NASH from the Amol cohort study were included in this study. MetS was diagnosed based on Adult Treatment Panel III criteria and HRQOL was measured using the 12-Item Short-Form Health Survey (SF-12) questionnaire (with 8 subscales and 2 summary components). A multivariable linear regression model was used to assess the independent effect of MetS on HRQOL. RESULTS: The mean age of the study population was 42 ± 13 years (range 18-82). The prevalence of MetS was 43.4% (n = 144) and the mean scores on the Physical Component Summary (PCS) and the Mental Component Summary were 72.4 ± 20.86 and 42.7 ± 12.42, respectively. The multivariable linear regression model showed that MetS was negatively associated with 4 subscales of HRQOL that included: role limitations due to physical problems (RP) (B = -14.05, p = 0.004), bodily pain (BP) (B = -7.37, p = 0.02), vitality (VT) (B = -7.72, p = 0.022), and role limitations due to emotional problems (RE) (B = -12.67, p = 0.005) after adjustment for other variables. Also, MetS had a borderline association with the general health and mental health subscales and the PCS (p < 0.1). CONCLUSION: In this study, there was a strong association between MetS and 4 subscales (RP, BP, VT, and RE) of HRQOL in patients with suspected NASH; this could be considered as a part of health policy to improve general health.
Authors: A A Dan; J B Kallman; A Wheeler; Z Younoszai; R Collantes; S Bondini; L Gerber; Z M Younossi Journal: Aliment Pharmacol Ther Date: 2007-09-15 Impact factor: 8.171
Authors: Mehmet Sayiner; Maria Stepanova; Huong Pham; Bashir Noor; Mercedes Walters; Zobair M Younossi Journal: BMJ Open Gastroenterol Date: 2016-08-16