| Literature DB >> 19505826 |
Christopher McGuigan1, Mary Rose Kelleher, Plinio Perrone, Sinead Mulready, Giovanna Luoni, Felice Daverio, Sonal Rajyaguru, Sophie Le Pogam, Isabel Najera, Joseph A Martin, Klaus Klumpp, David B Smith.
Abstract
We report the design, synthesis and evaluation of a family of ca 50 phosphoramidate ProTides of the potent anti-HCV compound 4'-azidocytidine (R1479), with variation on the ester, amino acid and aryl moiety of the ProTide. Sub-muM inhibitors of HCV emerge. The compounds are all non-cytotoxic in the replicon assay. We herein report detailed SARs for each of the regions of the ProTide.Entities:
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Year: 2009 PMID： 19505826 DOI： 10.1016/j.bmcl.2009.05.099
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823