| Literature DB >> 19500884 |
Arthur E Kümmerle1, Juliana M Raimundo, Carla M Leal, Givanildo S da Silva, Tatiane L Balliano, Mariano A Pereira, Carlos A de Simone, Roberto T Sudo, Gisele Zapata-Sudo, Carlos A M Fraga, Eliezer J Barreiro.
Abstract
In this report we disclose the synthesis, vasodilatory activity, and identification of bioactive conformation of new N-acylhydrazone and N-methyl-N-acylhydrazone derivatives, structurally designed by bioisosteric replacements of previously described cardioactive compounds LASSBio-294 and its N-methyl derivative LASSBio-785. Some of these novel derivatives presented improved vasorelaxant properties, being new cardiovascular drug candidates.Entities:
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Year: 2009 PMID： 19500884 DOI： 10.1016/j.ejmech.2009.04.044
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514