| Literature DB >> 19498431 |
David Schiff1, Benjamin W Purow.
Abstract
Most grade II and grade III gliomas, as well as the secondary glioblastomas that arise from these tumors, possess point mutations that affect the substrate binding site of isocitrate dehydrogenase. These mutations are essentially unique to gliomas, seem to represent an early step in gliomagenesis, and confer a favorable prognosis.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19498431 DOI： 10.1038/nrneurol.2009.57
Source DB: PubMed Journal: Nat Rev Neurol ISSN： 1759-4758 Impact factor: 42.937