Literature DB >> 19495122

Contrast and depth enhancement in two-photon microscopy of human skin ex vivo by use of optical clearing agents.

R Cicchi, D Sampson, D Massi, F Pavone.   

Abstract

We investigate the application of hyperosmotic optical clearing agents to improve the image contrast and penetration depth in two-photon microscopy of human dermis ex vivo. We show that the agents glycerol, propylene glycol, and glucose all convey significant improvements and we provide results on their dynamic behaviour and the reversibility of the effect. At suitable concentrations, such agents have the potential to be compatible with living tissue and may possibly enhance in-vivo deep-tissue imaging.

Entities:  

Year:  2005        PMID： 19495122     DOI： 10.1364/opex.13.002337

Source DB:  PubMed          Journal:  Opt Express        ISSN： 1094-4087            Impact factor:   3.894


  21 in total

1.  Characteristics of scar margin dynamic with time based on multiphoton microscopy.

Authors:  Xiaoqin Zhu; Shuangmu Zhuo; Liqin Zheng; Xingshan Jiang; Jianxin Chen; Bifang Lin
Journal:  Lasers Med Sci       Date:  2010-10-20       Impact factor: 3.161

2.  Enhancement of imaging depth in turbid media using a wide area detector.

Authors:  Viera Crosignani; Alexander S Dvornikov; Enrico Gratton
Journal:  J Biophotonics       Date:  2011-03-18       Impact factor: 3.207

3.  Maximum imaging depth of two-photon autofluorescence microscopy in epithelial tissues.

Authors:  Nicholas J Durr; Christian T Weisspfennig; Benjamin A Holfeld; Adela Ben-Yakar
Journal:  J Biomed Opt       Date:  2011-02       Impact factor: 3.170

4.  Accessing to arteriovenous blood flow dynamics response using combined laser speckle contrast imaging and skin optical clearing.

Authors:  Rui Shi; Min Chen; Valery V Tuchin; Dan Zhu
Journal:  Biomed Opt Express       Date:  2015-05-06       Impact factor: 3.732

5.  Multiphoton microscopy for label-free identification of intramural metastasis in human esophageal squamous cell carcinoma.

Authors:  Jian Xu; Deyong Kang; Yaping Zeng; Shuangmu Zhuo; Xiaoqin Zhu; Liwei Jiang; Jianxin Chen; Jiangbo Lin
Journal:  Biomed Opt Express       Date:  2017-06-21       Impact factor: 3.732

6.  Enhancement of short coherence digital holographic microscopy by optical clearing.

Authors:  Zhiyuan Shen; Xiaorui Guo; Yilong Zhang; Dongmei Li; Yonghong He
Journal:  Biomed Opt Express       Date:  2017-03-02       Impact factor: 3.732

7.  An automated approach for three-dimensional quantification of fibrillar structures in optically cleared soft biological tissues.

Authors:  Andreas J Schriefl; Heimo Wolinski; Peter Regitnig; Sepp D Kohlwein; Gerhard A Holzapfel
Journal:  J R Soc Interface       Date:  2012-12-26       Impact factor: 4.118

8.  In-vivo and ex-vivo optical clearing methods for biological tissues: review.

Authors:  Irene Costantini; Riccardo Cicchi; Ludovico Silvestri; Francesco Vanzi; Francesco Saverio Pavone
Journal:  Biomed Opt Express       Date:  2019-09-19       Impact factor: 3.732

9.  Optical clearing of skin enhanced with hyaluronic acid for increased contrast of optoacoustic imaging.

Authors:  Anton Liopo; Richard Su; Dmitri A Tsyboulski; Alexander A Oraevsky
Journal:  J Biomed Opt       Date:  2016-08       Impact factor: 3.170

10.  Deep tissue fluorescence imaging and in vivo biological applications.

Authors:  Viera Crosignani; Alexander Dvornikov; Jose S Aguilar; Chiara Stringari; Robert Edwards; William W Mantulin; Enrico Gratton
Journal:  J Biomed Opt       Date:  2012-11       Impact factor: 3.170
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