PURPOSE: Triple-negativity breast cancer (TNBC), being negative for the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor 2, represents a subgroup of breast cancer with a poor clinical outcome. The aim of the study was to determine whether TNBC is associated with lymphangiogenesis in node-negative breast carcinomas. METHODS: The authors investigated the clinicopathologic characteristics, lymphatic vessel density (LVD), and expression of 2 lymphangiogenic factors, vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor D (VEGF-D), in 21 lymph node-negative TNBCs and 70 lymph node-negative non-TNBCs. RESULTS: TNBC correlated with younger age (below 35 year) and higher histological grade. It also correlated with a higher intratumoral and peritumoral LVD, positive lymphatic invasion, and positive VEGF-C and VEGF-D expression. CONCLUSIONS: For the first time, this study indicated a link between triple-negativity breast cancer and lymphangiogenesis. Lymphangiogenesis might help explain the special malignant phonotype of breast cancer, and lymphangiogenesis inhibitors might be a novel choice for triple-negativity breast cancer patients.
PURPOSE: Triple-negativity breast cancer (TNBC), being negative for the estrogen receptor, the progesterone receptor, and the humanepidermal growth factor receptor 2, represents a subgroup of breast cancer with a poor clinical outcome. The aim of the study was to determine whether TNBC is associated with lymphangiogenesis in node-negative breast carcinomas. METHODS: The authors investigated the clinicopathologic characteristics, lymphatic vessel density (LVD), and expression of 2 lymphangiogenic factors, vascular endothelial growth factor C (VEGF-C) and vascular endothelial growth factor D (VEGF-D), in 21 lymph node-negative TNBCs and 70 lymph node-negative non-TNBCs. RESULTS:TNBC correlated with younger age (below 35 year) and higher histological grade. It also correlated with a higher intratumoral and peritumoral LVD, positive lymphatic invasion, and positive VEGF-C and VEGF-D expression. CONCLUSIONS: For the first time, this study indicated a link between triple-negativity breast cancer and lymphangiogenesis. Lymphangiogenesis might help explain the special malignant phonotype of breast cancer, and lymphangiogenesis inhibitors might be a novel choice for triple-negativity breast cancerpatients.
Authors: Leonel F Hernandez-Aya; Mariana Chavez-Macgregor; Xiudong Lei; Funda Meric-Bernstam; Thomas A Buchholz; Limin Hsu; Aysegul A Sahin; Kim-Anh Do; Vicente Valero; Gabriel N Hortobagyi; Ana Maria Gonzalez-Angulo Journal: J Clin Oncol Date: 2011-05-23 Impact factor: 44.544
Authors: Anna Goussia; Nafsika Simou; Flora Zagouri; Kyriaki Manousou; Georgios Lazaridis; Helen Gogas; Angelos Koutras; Maria Sotiropoulou; George Pentheroudakis; Dimitrios Bafaloukos; Christos Markopoulos; Helen Patsea; Christos Christodoulou; Pavlos Papakostas; Thomas Zaramboukas; Epaminontas Samantas; Paris Kosmidis; Vasileios Venizelos; Charisios Karanikiotis; George Papatsibas; Grigorios Xepapadakis; Konstantine T Kalogeras; Christina Bamia; Meletios-Athanassios Dimopoulos; Vassiliki Malamou-Mitsi; George Fountzilas; Anna Batistatou Journal: PLoS One Date: 2018-07-31 Impact factor: 3.240
Authors: Rachel Evans; Fabian Flores-Borja; Sina Nassiri; Elena Miranda; Katherine Lawler; Anita Grigoriadis; James Monypenny; Cheryl Gillet; Julie Owen; Peter Gordon; Victoria Male; Anthony Cheung; Farzana Noor; Paul Barber; Rebecca Marlow; Erika Francesch-Domenech; Gilbert Fruhwirth; Mario Squadrito; Borivoj Vojnovic; Andrew Tutt; Frederic Festy; Michele De Palma; Tony Ng Journal: Cell Rep Date: 2019-05-14 Impact factor: 9.423