Literature DB >> 19488046

The heritability of general cognitive ability increases linearly from childhood to young adulthood.

C M A Haworth1, M J Wright, M Luciano, N G Martin, E J C de Geus, C E M van Beijsterveldt, M Bartels, D Posthuma, D I Boomsma, O S P Davis, Y Kovas, R P Corley, J C Defries, J K Hewitt, R K Olson, S-A Rhea, S J Wadsworth, W G Iacono, M McGue, L A Thompson, S A Hart, S A Petrill, D Lubinski, R Plomin.   

Abstract

Although common sense suggests that environmental influences increasingly account for individual differences in behavior as experiences accumulate during the course of life, this hypothesis has not previously been tested, in part because of the large sample sizes needed for an adequately powered analysis. Here we show for general cognitive ability that, to the contrary, genetic influence increases with age. The heritability of general cognitive ability increases significantly and linearly from 41% in childhood (9 years) to 55% in adolescence (12 years) and to 66% in young adulthood (17 years) in a sample of 11 000 pairs of twins from four countries, a larger sample than all previous studies combined. In addition to its far-reaching implications for neuroscience and molecular genetics, this finding suggests new ways of thinking about the interface between nature and nurture during the school years. Why, despite life's 'slings and arrows of outrageous fortune', do genetically driven differences increasingly account for differences in general cognitive ability? We suggest that the answer lies with genotype-environment correlation: as children grow up, they increasingly select, modify and even create their own experiences in part based on their genetic propensities.

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Year:  2009        PMID: 19488046      PMCID: PMC2889158          DOI: 10.1038/mp.2009.55

Source DB:  PubMed          Journal:  Mol Psychiatry        ISSN: 1359-4184            Impact factor:   15.992


  36 in total

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4.  A longitudinal twin study on IQ, executive functioning, and attention problems during childhood and early adolescence.

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5.  Netherlands Twin Register: from twins to twin families.

Authors:  Dorret I Boomsma; Eco J C de Geus; Jacqueline M Vink; Janine H Stubbe; Marijn A Distel; Jouke-Jan Hottenga; Danielle Posthuma; Toos C E M van Beijsterveldt; James J Hudziak; Meike Bartels; Gonneke Willemsen
Journal:  Twin Res Hum Genet       Date:  2006-12       Impact factor: 1.587

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Authors:  R C Nichols; W C Bilbro
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8.  Adjustment of twin data for the effects of age and sex.

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Authors:  M P Watkins; W Meredith
Journal:  Behav Genet       Date:  1981-01       Impact factor: 2.805

10.  Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays.

Authors:  L M Butcher; O S P Davis; I W Craig; R Plomin
Journal:  Genes Brain Behav       Date:  2008-01-22       Impact factor: 3.449

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  161 in total

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3.  Intellectual interest mediates gene × socioeconomic status interaction on adolescent academic achievement.

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5.  Genes contributing to subcortical volumes and intellectual ability implicate the thalamus.

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Review 6.  The paradox of intelligence: Heritability and malleability coexist in hidden gene-environment interplay.

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7.  Strong genetic overlap between executive functions and intelligence.

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8.  Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories.

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Review 9.  Cross-Study Differences in the Etiology of Reading Comprehension: a Meta-Analytical Review of Twin Studies.

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10.  Colorado Twin Registry: an update.

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