L Lipworth1, M Rossi2, J K McLaughlin3, E Negri2, R Talamini4, F Levi5, S Franceschi6, C La Vecchia7. 1. International Epidemiology Institute, Rockville, MD; Department of Preventive Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA. Electronic address: loren@iei.us. 2. Department of Epidemiology, Institute of Pharmacologic Research "Mario Negri", Milan. 3. International Epidemiology Institute, Rockville, MD; Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA. 4. Epidemiology and Biostatistics Unit, Oncology Referral Center, Aviano (PN), Italy. 5. Cancer Epidemiology Unit and Cancer Registries of Vaud and Neuchatel, Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland. 6. Epidemiology and Biology Cluster, International Agency for Research on Cancer, Lyon, France. 7. Department of Epidemiology, Institute of Pharmacologic Research "Mario Negri", Milan; Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA; Institute of Medical Statistics and Biometrics "G. A. Maccacaro", University of Milan, Milan, Italy.
Abstract
BACKGROUND: Data on the association between vitamin D and upper digestive tract neoplasms are limited. METHODS: In two case-control studies in Italy, we examined the relation between dietary vitamin D intake and squamous cell carcinoma of the esophagus (SCCE; 304 cases) and oral/pharyngeal cancer (804 cases). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by multiple logistic regression. RESULTS: Adjusted ORs for SCCE and oral/pharyngeal cancer were 0.58 (95% CI 0.39-0.86) and 0.76 (95% CI 0.60-0.94), respectively, for the highest tertile of vitamin D intake. Using a reference group of those in the highest tertile of vitamin D who were never/former smokers, ORs were 8.7 (95% CI 4.1-18.7) for SCCE and 10.4 (95% CI 6.9-15.5) for oral/pharyngeal cancer among heavy smokers in the lowest vitamin D tertile; similarly, compared with those in the highest tertile of vitamin D who drank <3 alcoholic drinks/day, corresponding ORs were 41.9 (95% CI 13.7-128.6) for SCCE and 8.5 (95% CI 5.7-12.5) for oral/pharyngeal cancer, among heavy alcohol drinkers in the lowest vitamin D tertile. CONCLUSION: We observed inverse associations between dietary vitamin D intake and risk of SCCE and, perhaps, oral/pharyngeal cancer, which were most pronounced among heavy current smokers and heavy consumers of alcohol.
BACKGROUND: Data on the association between vitamin D and upper digestive tract neoplasms are limited. METHODS: In two case-control studies in Italy, we examined the relation between dietary vitamin D intake and squamous cell carcinoma of the esophagus (SCCE; 304 cases) and oral/pharyngeal cancer (804 cases). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by multiple logistic regression. RESULTS: Adjusted ORs for SCCE and oral/pharyngeal cancer were 0.58 (95% CI 0.39-0.86) and 0.76 (95% CI 0.60-0.94), respectively, for the highest tertile of vitamin D intake. Using a reference group of those in the highest tertile of vitamin D who were never/former smokers, ORs were 8.7 (95% CI 4.1-18.7) for SCCE and 10.4 (95% CI 6.9-15.5) for oral/pharyngeal cancer among heavy smokers in the lowest vitamin D tertile; similarly, compared with those in the highest tertile of vitamin D who drank <3 alcoholic drinks/day, corresponding ORs were 41.9 (95% CI 13.7-128.6) for SCCE and 8.5 (95% CI 5.7-12.5) for oral/pharyngeal cancer, among heavy alcohol drinkers in the lowest vitamin D tertile. CONCLUSION: We observed inverse associations between dietary vitamin D intake and risk of SCCE and, perhaps, oral/pharyngeal cancer, which were most pronounced among heavy current smokers and heavy consumers of alcohol.
Authors: Markus Gugatschka; Karl Kiesler; Barbara Obermayer-Pietsch; Andrea Groselj-Strele; Antonia Griesbacher; Gerhard Friedrich Journal: Eur Arch Otorhinolaryngol Date: 2011-01-08 Impact factor: 2.503
Authors: Robert L Brunner; Jean Wactawski-Wende; Bette J Caan; Barbara B Cochrane; Rowan T Chlebowski; Margery L S Gass; Elizabeth T Jacobs; Andrea Z LaCroix; Dorothy Lane; Joseph Larson; Karen L Margolis; Amy E Millen; Gloria E Sarto; Mara Z Vitolins; Robert B Wallace Journal: Nutr Cancer Date: 2011-07-20 Impact factor: 2.900
Authors: Liqing Zhou; Xiaojiao Zhang; Xuechao Chen; Li Liu; Chao Lu; Xiaohu Tang; Juan Shi; Meng Li; Mo Zhou; Zhouwei Zhang; Lingchen Xiao; Ming Yang Journal: Int J Clin Exp Med Date: 2012-01-15
Authors: Vincent T Janmaat; Anouk Van De Winkel; Maikel P Peppelenbosch; Manon C W Spaander; André G Uitterlinden; Farzin Pourfarzad; Hugo W Tilanus; Agnieszka M Rygiel; Leon M G Moons; Pascal P Arp; Kausilia K Krishnadath; Ernst J Kuipers; Luc J W Van Der Laan Journal: Mol Med Date: 2015-04-21 Impact factor: 6.354