| Literature DB >> 19481975 |
Shomyseh Sanjabi1, Lauren A Zenewicz, Masahito Kamanaka, Richard A Flavell.
Abstract
Cytokines play a major role in maintaining lymphocyte homeostasis under both steady-state and inflammatory conditions. Unregulated lymphocytes in steady-state conditions can lead to autoimmunity, whereas during inflammation they can cause excessive tissue damage. Regulatory cytokines function in combination with other environmental signals to properly modulate the function and the extent of lymphocyte activation. Many recent studies have highlighted the importance of regulatory cytokines in controlling the differentiation and function of lymphocytes under steady-state and inflammatory conditions, as well as minimizing tissue damage.Entities:
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Year: 2009 PMID： 19481975 PMCID： PMC2755239 DOI： 10.1016/j.coph.2009.04.008
Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547