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Literature DB >> 19478492

Role of animal studies in the design of clinical trials.

Edward D Hall, Richard J Traystman.

Abstract

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2009 PMID： 19478492 PMCID： PMC2811045 DOI： 10.1159/000209470

Source DB: PubMed Journal: Front Neurol Neurosci ISSN： 0300-5186

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54 in total

1. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection.

Authors: D M Basso; M S Beattie; J C Bresnahan
Journal: Exp Neurol Date: 1996-06 Impact factor: 5.330

2. Double-blind, randomized, vehicle-controlled study of high-dose tirilazad mesylate in women with aneurysmal subarachnoid hemorrhage. Part I. A cooperative study in Europe, Australia, New Zealand, and South Africa.

Authors: G Lanzino; N F Kassell; N W Dorsch; A Pasqualin; L Brandt; P Schmiedek; L L Truskowski; W M Alves
Journal: J Neurosurg Date: 1999-06 Impact factor: 5.115

3. Double-blind, randomized, vehicle-controlled study of high-dose tirilazad mesylate in women with aneurysmal subarachnoid hemorrhage. Part II. A cooperative study in North America.

Authors: G Lanzino; N F Kassell
Journal: J Neurosurg Date: 1999-06 Impact factor: 5.115

4. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study.

Authors: M B Bracken; M J Shepard; T R Holford; L Leo-Summers; E F Aldrich; M Fazl; M Fehlings; D L Herr; P W Hitchon; L F Marshall; R P Nockels; V Pascale; P L Perot; J Piepmeier; V K Sonntag; F Wagner; J E Wilberger; H R Winn; W Young
Journal: JAMA Date: 1997-05-28 Impact factor: 56.272

5. Neuroprotective effects of the novel brain-penetrating pyrrolopyrimidine antioxidants U-101033E and U-104067F against post-ischemic degeneration of nigrostriatal neurons.

Authors: P K Andrus; T J Fleck; J A Oostveen; E D Hall
Journal: J Neurosci Res Date: 1997-03-15 Impact factor: 4.164

6. Nimodipine in traumatic subarachnoid haemorrhage: a re-analysis of the HIT I and HIT II trials.

Authors: G D Murray; G M Teasdale; H Schmitz
Journal: Acta Neurochir (Wien) Date: 1996 Impact factor: 2.216

7. Estrogen-mediated neuroprotection after experimental stroke in male rats.

Authors: T J Toung; R J Traystman; P D Hurn
Journal: Stroke Date: 1998-08 Impact factor: 7.914

8. A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury.

Authors: L F Marshall; A I Maas; S B Marshall; A Bricolo; M Fearnside; F Iannotti; M R Klauber; J Lagarrigue; R Lobato; L Persson; J D Pickard; J Piek; F Servadei; G N Wellis; G F Morris; E D Means; B Musch
Journal: J Neurosurg Date: 1998-10 Impact factor: 5.115

9. Tirilazad widens the therapeutic window for riluzole-induced attenuation of progressive cortical degeneration in an infant rat model of the shaken baby syndrome.

Authors: S L Smith; E D Hall
Journal: J Neurotrauma Date: 1998-09 Impact factor: 5.269

10. Infant rat model of the shaken baby syndrome: preliminary characterization and evidence for the role of free radicals in cortical hemorrhaging and progressive neuronal degeneration.

Authors: S L Smith; P K Andrus; D D Gleason; E D Hall
Journal: J Neurotrauma Date: 1998-09 Impact factor: 5.269

12 in total

Review 1. Investigational agents for treatment of traumatic brain injury.

Authors: Ye Xiong; Yanlu Zhang; Asim Mahmood; Michael Chopp
Journal: Expert Opin Investig Drugs Date: 2015-03-01 Impact factor: 6.206

2. Establishing a Clinically Relevant Large Animal Model Platform for TBI Therapy Development: Using Cyclosporin A as a Case Study.

Authors: Susan S Margulies; Todd Kilbaugh; Sarah Sullivan; Colin Smith; Kathleen Propert; Melissa Byro; Kristen Saliga; Beth A Costine; Ann-Christine Duhaime
Journal: Brain Pathol Date: 2015-05 Impact factor: 6.508

Role of animal studies in the design of clinical trials.

1. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection.

2. Double-blind, randomized, vehicle-controlled study of high-dose tirilazad mesylate in women with aneurysmal subarachnoid hemorrhage. Part I. A cooperative study in Europe, Australia, New Zealand, and South Africa.

3. Double-blind, randomized, vehicle-controlled study of high-dose tirilazad mesylate in women with aneurysmal subarachnoid hemorrhage. Part II. A cooperative study in North America.

4. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study.

5. Neuroprotective effects of the novel brain-penetrating pyrrolopyrimidine antioxidants U-101033E and U-104067F against post-ischemic degeneration of nigrostriatal neurons.

6. Nimodipine in traumatic subarachnoid haemorrhage: a re-analysis of the HIT I and HIT II trials.

7. Estrogen-mediated neuroprotection after experimental stroke in male rats.

8. A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury.

9. Tirilazad widens the therapeutic window for riluzole-induced attenuation of progressive cortical degeneration in an infant rat model of the shaken baby syndrome.

10. Infant rat model of the shaken baby syndrome: preliminary characterization and evidence for the role of free radicals in cortical hemorrhaging and progressive neuronal degeneration.

Review 1. Investigational agents for treatment of traumatic brain injury.

2. Establishing a Clinically Relevant Large Animal Model Platform for TBI Therapy Development: Using Cyclosporin A as a Case Study.

Review 3. Sexual dimorphism in ischemic stroke: lessons from the laboratory.

4. Importance of Systematic Reviews and Meta-analyses of Animal Studies: Challenges for Animal-to-Human Translation.

Review 5. Translational spinal cord injury research: preclinical guidelines and challenges.

Review 6. An update on spinal cord injury research.

Review 7. Middle cerebral artery occlusion model in rodents: methods and potential pitfalls.

Review 8. Function of microglia and macrophages in secondary damage after spinal cord injury.

Review 9. MSCs-Derived Exosomes and Neuroinflammation, Neurogenesis and Therapy of Traumatic Brain Injury.

Review 10. Inflammogenesis of Secondary Spinal Cord Injury.