Literature DB >> 19477950

Minireview: live and let die: molecular effects of glucocorticoids on bone cells.

Lorenz C Hofbauer1, Martina Rauner.   

Abstract

Glucocorticoids (GCs) are efficient drugs that are used to treat various immune-mediated diseases, but their long-term administration is associated with multiple metabolic side effects, including osteoporosis. Molecular analyses of the mechanisms exerted by the GC receptor have resulted in the development of GC receptor agonists that selectively repress or activate GC target genes. This review summarizes the cellular and molecular effects of GCs on bone cells and highlights the critical signaling pathways that may evolve into future therapeutic strategies.

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Year:  2009        PMID： 19477950      PMCID： PMC5419139          DOI： 10.1210/me.2009-0069

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN： 0888-8809


  51 in total

1.  Colocalization of glucocorticoid and mineralocorticoid receptors in human bone.

Authors:  S Beavan; A Horner; S Bord; D Ireland; J Compston
Journal:  J Bone Miner Res       Date:  2001-08       Impact factor: 6.741

2.  Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects.

Authors:  Heike Schäcke; Arndt Schottelius; Wolf-Dietrich Döcke; Peter Strehlke; Stefan Jaroch; Norbert Schmees; Hartmut Rehwinkel; Hartwig Hennekes; Khusru Asadullah
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-23       Impact factor: 11.205

3.  11beta-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation.

Authors:  M Eijken; M Hewison; M S Cooper; F H de Jong; H Chiba; P M Stewart; A G Uitterlinden; H A P Pols; J P T M van Leeuwen
Journal:  Mol Endocrinol       Date:  2004-12-09

4.  Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.

Authors:  Christopher F Thompson; Nazia Quraishi; Amjad Ali; James R Tata; Milton L Hammond; James M Balkovec; Monica Einstein; Lan Ge; Georgianna Harris; Theresa M Kelly; Paul Mazur; Shilpa Pandit; Joseph Santoro; Ayesha Sitlani; Chuanlin Wang; Joanne Williamson; Douglas K Miller; Ting-ting D Yamin; Chris M Thompson; Edward A O'Neill; Dennis Zaller; Michael J Forrest; Ester Carballo-Jane; Silvi Luell
Journal:  Bioorg Med Chem Lett       Date:  2005-04-15       Impact factor: 2.823

Review 5.  Non-genomic glucocorticoid effects to provide the basis for new drug developments.

Authors:  In-Ho Song; Frank Buttgereit
Journal:  Mol Cell Endocrinol       Date:  2006-01-18       Impact factor: 4.102

6.  Fat conversion of femoral marrow in glucocorticoid-treated patients: a cross-sectional and longitudinal study with magnetic resonance imaging.

Authors:  B C Vande Berg; J Malghem; F E Lecouvet; J P Devogelaer; B Maldague; F A Houssiau
Journal:  Arthritis Rheum       Date:  1999-07

7.  Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice.

Authors:  Hong Zhou; Wendy Mak; Robert Kalak; Janine Street; Colette Fong-Yee; Yu Zheng; Colin R Dunstan; Markus J Seibel
Journal:  Development       Date:  2009-02       Impact factor: 6.868

8.  Quantitative analysis for human glucocorticoid receptor alpha/beta mRNA in IBD.

Authors:  Fumika Orii; Toshifumi Ashida; Masafumi Nomura; Atsuo Maemoto; Takanori Fujiki; Tokiyoshi Ayabe; Shinjiro Imai; Yusuke Saitoh; Yutaka Kohgo
Journal:  Biochem Biophys Res Commun       Date:  2002-09-06       Impact factor: 3.575

9.  Identification of dissociated non-steroidal glucocorticoid receptor agonists.

Authors:  Daniel Kuzmich; Tom Kirrane; John Proudfoot; Younes Bekkali; Renee Zindell; Laura Beck; Richard Nelson; Cheng-Kon Shih; Alison J Kukulka; Zofia Paw; Patty Reilly; Rodney Deleon; Mario Cardozo; Gerald Nabozny; David Thomson
Journal:  Bioorg Med Chem Lett       Date:  2007-07-25       Impact factor: 2.823

10.  Transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone.

Authors:  Lorin B Sher; Henning W Woitge; Douglas J Adams; Gloria A Gronowicz; Zygmunt Krozowski; John R Harrison; Barbara E Kream
Journal:  Endocrinology       Date:  2003-11-14       Impact factor: 4.736
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  30 in total

Review 1.  Bisphosphonates in the treatment of glucocorticoid-induced osteoporosis: pros.

Authors:  Maurizio Rossini; Giovanni Orsolini; Ombretta Viapiana; Silvano Adami; Davide Gatti
Journal:  Endocrine       Date:  2015-02-04       Impact factor: 3.633

2.  [Local and systemic bone effects of rheumatoid arthritis].

Authors:  M Rauner; L C Hofbauer; M Aringer
Journal:  Z Rheumatol       Date:  2012-12       Impact factor: 1.372

3.  Kidney transplantation with early corticosteroid withdrawal: paradoxical effects at the central and peripheral skeleton.

Authors:  Sapna P Iyer; Lucas E Nikkel; Kyle K Nishiyama; Elzbieta Dworakowski; Serge Cremers; Chiyuan Zhang; Donald J McMahon; Stephanie Boutroy; X Sherry Liu; Lloyd E Ratner; David J Cohen; X Edward Guo; Elizabeth Shane; Thomas L Nickolas
Journal:  J Am Soc Nephrol       Date:  2014-02-07       Impact factor: 10.121

Review 4.  A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis.

Authors:  S Lekamwasam; J D Adachi; D Agnusdei; J Bilezikian; S Boonen; F Borgström; C Cooper; A Diez Perez; R Eastell; L C Hofbauer; J A Kanis; B L Langdahl; O Lesnyak; R Lorenc; E McCloskey; O D Messina; N Napoli; B Obermayer-Pietsch; S H Ralston; P N Sambrook; S Silverman; M Sosa; J Stepan; G Suppan; D A Wahl; J E Compston
Journal:  Osteoporos Int       Date:  2012-03-21       Impact factor: 4.507

Review 5.  Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment.

Authors:  Pojchong Chotiyarnwong; Eugene V McCloskey
Journal:  Nat Rev Endocrinol       Date:  2020-04-14       Impact factor: 43.330

Review 6.  Autophagy as a target for glucocorticoid-induced osteoporosis therapy.

Authors:  Gengyang Shen; Hui Ren; Qi Shang; Ting Qiu; Xiang Yu; Zhida Zhang; Jinjing Huang; Wenhua Zhao; Yuzhuo Zhang; Xiaobing Jiang
Journal:  Cell Mol Life Sci       Date:  2018-02-09       Impact factor: 9.261

7.  Retinoids stimulate periosteal bone resorption by enhancing the protein RANKL, a response inhibited by monomeric glucocorticoid receptor.

Authors:  H Herschel Conaway; Amir Pirhayati; Emma Persson; Ulrika Pettersson; Olle Svensson; Catharina Lindholm; Petra Henning; Jan Tuckermann; Ulf H Lerner
Journal:  J Biol Chem       Date:  2011-06-29       Impact factor: 5.157

Review 8.  Glucocorticoid-induced osteoporosis: who to treat with what agent?

Authors:  René Rizzoli; Emmanuel Biver
Journal:  Nat Rev Rheumatol       Date:  2014-11-11       Impact factor: 20.543

Review 9.  Advances in treatment of glucocorticoid-induced osteoporosis.

Authors:  Emory Hsu; Mark Nanes
Journal:  Curr Opin Endocrinol Diabetes Obes       Date:  2017-12       Impact factor: 3.243

10.  Bone status in adults with early-onset juvenile idiopathic arthritis following 1-year anti-TNFα therapy and discontinuation of glucocorticoids.

Authors:  Kristyna Brabnikova Maresova; Katerina Jarosova; Karel Pavelka; Jan J Stepan
Journal:  Rheumatol Int       Date:  2013-02-01       Impact factor: 2.631
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