| Literature DB >> 15808489 |
Christopher F Thompson1, Nazia Quraishi, Amjad Ali, James R Tata, Milton L Hammond, James M Balkovec, Monica Einstein, Lan Ge, Georgianna Harris, Theresa M Kelly, Paul Mazur, Shilpa Pandit, Joseph Santoro, Ayesha Sitlani, Chuanlin Wang, Joanne Williamson, Douglas K Miller, Ting-ting D Yamin, Chris M Thompson, Edward A O'Neill, Dennis Zaller, Michael J Forrest, Ester Carballo-Jane, Silvi Luell.
Abstract
A series of novel ligands for the glucocorticoid receptor containing two heterocycles were synthesized. These compounds were investigated for a dissociative profile using transrepression and transactivation assays. Several compounds were tested in vivo and showed the ability to reduce inflammation in a mouse.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15808489 DOI： 10.1016/j.bmcl.2005.02.009
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823