BACKGROUND AND OBJECTIVES: This study investigated the prognostic impact of lymphatic invasion on the outcome of patients with node-negative gastric cancer. METHODS: A total of 828 patients with node-negative gastric cancer who underwent curative gastrectomy were reviewed retrospectively. The clinicopathological features and prognoses of patients with lymphatic invasion were compared to those of patients without such invasion. RESULTS: The total rate of lymphatic invasion was 18.2% in node-negative gastric cancers, with a significant difference between early gastric cancers (9.8%) and advanced gastric cancers (49.2%). The presence of lymphatic invasion correlated significantly with tumor location, size and depth of tumor (P < 0.01). Lymphatic invasion was significantly associated with a poorer overall survival in node-negative gastric cancer patients on univariate analysis (P < 0.001) as well as multivariate analysis (P < 0.01). CONCLUSIONS: Lymphatic invasion provides additional useful information that could be applied to identify patients at high risk for recurrence who might be candidates for adjuvant therapies in patients with node-negative gastric cancers.
BACKGROUND AND OBJECTIVES: This study investigated the prognostic impact of lymphatic invasion on the outcome of patients with node-negative gastric cancer. METHODS: A total of 828 patients with node-negative gastric cancer who underwent curative gastrectomy were reviewed retrospectively. The clinicopathological features and prognoses of patients with lymphatic invasion were compared to those of patients without such invasion. RESULTS: The total rate of lymphatic invasion was 18.2% in node-negative gastric cancers, with a significant difference between early gastric cancers (9.8%) and advanced gastric cancers (49.2%). The presence of lymphatic invasion correlated significantly with tumor location, size and depth of tumor (P < 0.01). Lymphatic invasion was significantly associated with a poorer overall survival in node-negative gastric cancerpatients on univariate analysis (P < 0.001) as well as multivariate analysis (P < 0.01). CONCLUSIONS: Lymphatic invasion provides additional useful information that could be applied to identify patients at high risk for recurrence who might be candidates for adjuvant therapies in patients with node-negative gastric cancers.
Authors: Alisa N Blumenthaler; Timothy E Newhook; Naruhiko Ikoma; Jeannelyn S Estrella; Mariela Blum Murphy; Prajnan Das; Bruce D Minsky; Jaffer A Ajani; Paul F Mansfield; Brian D Badgwell Journal: J Surg Oncol Date: 2021-01-05 Impact factor: 3.454