BACKGROUND: Lymphatic and venous involvement is a critical factor in the curability assessment of endoscopically resected gastric cancers; however, the risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers remain unknown. METHODS: To identify risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers, we retrospectively reviewed a consecutive series of 1229 endoscopically resected gastric cancers in 1083 patients treated between January 2009 and December 2011. RESULTS: Lymphatic and venous involvement was detected in 57 (4.6%) and 32 (2.6%) lesions, respectively. A multivariate analysis identified a larger tumor size, deeper invasion (submucosal invasion or deeper), and the presence of a papillary or an undifferentiated-type adenocarcinoma component as independent risk factors for lymphatic involvement. As for venous involvement, deeper invasion (≥500 μm submucosal invasion), a macroscopically elevated type, and the presence of an undifferentiated-type adenocarcinoma component were identified as independent risk factors. CONCLUSIONS: The present study identified the independent risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers. The recognition of these risk factors would help in the selection of lesions that may require a particularly careful histological evaluation.
BACKGROUND: Lymphatic and venous involvement is a critical factor in the curability assessment of endoscopically resected gastric cancers; however, the risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers remain unknown. METHODS: To identify risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers, we retrospectively reviewed a consecutive series of 1229 endoscopically resected gastric cancers in 1083 patients treated between January 2009 and December 2011. RESULTS: Lymphatic and venous involvement was detected in 57 (4.6%) and 32 (2.6%) lesions, respectively. A multivariate analysis identified a larger tumor size, deeper invasion (submucosal invasion or deeper), and the presence of a papillary or an undifferentiated-type adenocarcinoma component as independent risk factors for lymphatic involvement. As for venous involvement, deeper invasion (≥500 μm submucosal invasion), a macroscopically elevated type, and the presence of an undifferentiated-type adenocarcinoma component were identified as independent risk factors. CONCLUSIONS: The present study identified the independent risk factors for lymphatic and venous involvement in endoscopically resected gastric cancers. The recognition of these risk factors would help in the selection of lesions that may require a particularly careful histological evaluation.
Authors: H Isomoto; S Shikuwa; N Yamaguchi; E Fukuda; K Ikeda; H Nishiyama; K Ohnita; Y Mizuta; J Shiozawa; S Kohno Journal: Gut Date: 2008-11-10 Impact factor: 23.059
Authors: T Arigami; S Natsugoe; Y Uenosono; H Arima; Y Mataki; K Ehi; S Yanagida; S Ishigami; S Hokita; T Aikou Journal: Br J Cancer Date: 2005-09-19 Impact factor: 7.640
Authors: Hyun Jung Lee; Gwang Ha Kim; Do Youn Park; Young Keum Kim; Hye Kyung Jeon; Bong Eun Lee; Geun Am Song Journal: Gastric Cancer Date: 2017-03-07 Impact factor: 7.370
Authors: Byung-Hoon Min; Sun-Ju Byeon; Jun Haeng Lee; Kyoung-Mee Kim; Ji Yeong An; Min Gew Choi; Jun Ho Lee; Tae Sung Sohn; Jae Moon Bae; Sung Kim Journal: Gastric Cancer Date: 2017-12-26 Impact factor: 7.370