Literature DB >> 19473027

Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists.

Remo Guerrini1, Valeria Camarda, Claudio Trapella, Girolamo Caló, Anna Rizzi, Chiara Ruzza, Stella Fiorini, Erika Marzola, Rainer K Reinscheid, Domenico Regoli, Severo Salvadori.   

Abstract

Neuropeptide S (NPS) regulates various biological functions by activating the NPS receptor (NPSR). Previous studies demonstrated that the substitution of Gly(5) with d-amino acids generates NPSR antagonists. Eleven [d-Xaa(5)]NPS derivatives were synthesized and pharmacologically tested measuring [Ca(2+)](i) in HEK293(mNPSR) cells. The results confirmed that the [d-Xaa(5)] substitution promotes antagonist activity with potency inversely related to the side chain size and allowed identification of the novel potent NPSR peptide antagonist [(t)Bu-d-Gly(5)]NPS.

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Year:  2009        PMID： 19473027      PMCID： PMC2732566          DOI： 10.1021/jm900604g

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  25 in total

1.  Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I.

Authors:  Virginie Bernier; Rino Stocco; Michael J Bogusky; Joseph G Joyce; Christine Parachoniak; Karl Grenier; Michael Arget; Marie-Claude Mathieu; Gary P O'Neill; Deborah Slipetz; Michael A Crackower; Christopher M Tan; Alex G Therien
Journal:  J Biol Chem       Date:  2006-06-20       Impact factor: 5.157

2.  Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation.

Authors:  Adelheid L Roth; Erika Marzola; Anna Rizzi; Marika Arduin; Claudio Trapella; Corrado Corti; Raffaella Vergura; Prisca Martinelli; Severo Salvadori; Domenico Regoli; Mauro Corsi; Paolo Cavanni; Girolamo Caló; Remo Guerrini
Journal:  J Biol Chem       Date:  2006-05-23       Impact factor: 5.157

3.  Pharmacological characterization of human and murine neuropeptide s receptor variants.

Authors:  Rainer K Reinscheid; Yan-Ling Xu; Naoe Okamura; Joanne Zeng; Shinjae Chung; Rama Pai; Zhiwei Wang; Olivier Civelli
Journal:  J Pharmacol Exp Ther       Date:  2005-09-06       Impact factor: 4.030

4.  Peptide S is a novel potent inhibitor of voluntary and fast-induced food intake in rats.

Authors:  Bernard Beck; Brigitte Fernette; Alain Stricker-Krongrad
Journal:  Biochem Biophys Res Commun       Date:  2005-07-08       Impact factor: 3.575

5.  Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.

Authors:  Yan-Ling Xu; Rainer K Reinscheid; Salvador Huitron-Resendiz; Stewart D Clark; Zhiwei Wang; Steven H Lin; Fernando A Brucher; Joanne Zeng; Nga K Ly; Steven J Henriksen; Luis de Lecea; Olivier Civelli
Journal:  Neuron       Date:  2004-08-19       Impact factor: 17.173

6.  Anorexigenic effects of central neuropeptide S involve the hypothalamus in chicks (Gallus gallus).

Authors:  Mark A Cline; David C Godlove; Wint Nandar; Christie N Bowden; Brian C Prall
Journal:  Comp Biochem Physiol A Mol Integr Physiol       Date:  2007-08-21       Impact factor: 2.320

7.  Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system.

Authors:  Nazzareno Cannella; Daina Economidou; Marsida Kallupi; Serena Stopponi; Markus Heilig; Maurizio Massi; Roberto Ciccocioppo
Journal:  Neuropsychopharmacology       Date:  2009-03-25       Impact factor: 7.853

8.  Synthesis and biological activity of human neuropeptide S analogues modified in position 2.

Authors:  Valeria Camarda; Claudio Trapella; Girolamo Calo; Remo Guerrini; Anna Rizzi; Chiara Ruzza; Stella Fiorini; Erika Marzola; Rainer K Reinscheid; Domenico Regoli; Severo Salvadori
Journal:  J Med Chem       Date:  2008-01-09       Impact factor: 7.446

9.  Neuropeptide S stimulates the hypothalamo-pituitary-adrenal axis and inhibits food intake.

Authors:  Kirsty L Smith; Michael Patterson; Waljit S Dhillo; Sejal R Patel; Nina M Semjonous; James V Gardiner; Mohammad A Ghatei; Stephen R Bloom
Journal:  Endocrinology       Date:  2006-03-30       Impact factor: 4.736

10.  Conformation-activity relationship of neuropeptide S and some structural mutants: helicity affects their interaction with the receptor.

Authors:  Teodorico Tancredi; Remo Guerrini; Erika Marzola; Claudio Trapella; Girolamo Calo; Domenico Regoli; Rainer K Reinscheid; Valeria Camarda; Severo Salvadori; Piero Andrea Temussi
Journal:  J Med Chem       Date:  2007-08-15       Impact factor: 7.446
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  10 in total

1.  Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor.

Authors:  Samarjit Patnaik; Juan J Marugan; Ke Liu; Wei Zheng; Noel Southall; Seameen J Dehdashti; Annika Thorsell; Markus Heilig; Lauren Bell; Michelle Zook; Bob Eskay; Kyle R Brimacombe; Christopher P Austin
Journal:  J Med Chem       Date:  2013-11-11       Impact factor: 7.446

2.  Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity.

Authors:  David A Slattery; Roshan R Naik; Thomas Grund; Yi-Chun Yen; Simone B Sartori; Andrea Füchsl; Beate C Finger; Betina Elfving; Uwe Nordemann; Remo Guerrini; Girolamo Calo; Gregers Wegener; Aleksander A Mathé; Nicolas Singewald; Ludwig Czibere; Rainer Landgraf; Inga D Neumann
Journal:  J Neurosci       Date:  2015-03-18       Impact factor: 6.167

3.  Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat.

Authors:  Marsida Kallupi; Giordano de Guglielmo; Nazzareno Cannella; Hong Wu Li; Girolamo Caló; Remo Guerrini; Massimo Ubaldi; John J Renger; Victor N Uebele; Roberto Ciccocioppo
Journal:  Psychopharmacology (Berl)       Date:  2012-11-13       Impact factor: 4.530

4.  Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor.

Authors:  Joshua G McCoy; Juan J Marugan; Ke Liu; Wei Zheng; Noel Southall; Wenwei Huang; Markus Heilig; Christopher P Austin
Journal:  ACS Chem Neurosci       Date:  2010-08-18       Impact factor: 4.418

5.  Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).

Authors:  Claudio Trapella; Michela Pela; Luisa Del Zoppo; Girolamo Calo; Valeria Camarda; Chiara Ruzza; Alberto Cavazzini; Valentina Costa; Valerio Bertolasi; Rainer K Reinscheid; Severo Salvadori; Remo Guerrini
Journal:  J Med Chem       Date:  2011-04-05       Impact factor: 7.446

Review 6.  Translational approach to develop novel medications on alcohol addiction: focus on neuropeptides.

Authors:  Massimo Ubaldi; Angelo Bifone; Roberto Ciccocioppo
Journal:  Curr Opin Neurobiol       Date:  2013-05-03       Impact factor: 6.627

Review 7.  Pharmacology, Physiology and Genetics of the Neuropeptide S System.

Authors:  Rainer K Reinscheid; Chiara Ruzza
Journal:  Pharmaceuticals (Basel)       Date:  2021-04-23

8.  Multiple polymorphisms affect expression and function of the neuropeptide S receptor (NPSR1).

Authors:  Francesca Anedda; Marco Zucchelli; Danika Schepis; Anna Hellquist; Lucia Corrado; Sandra D'Alfonso; Adnane Achour; Gerald McInerney; Alejandro Bertorello; Mikael Lördal; Ragnar Befrits; Jan Björk; Francesca Bresso; Leif Törkvist; Jonas Halfvarson; Juha Kere; Mauro D'Amato
Journal:  PLoS One       Date:  2011-12-21       Impact factor: 3.240

9.  In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative.

Authors:  Chiara Ruzza; Anna Rizzi; Davide Malfacini; Alice Pulga; Salvatore Pacifico; Severo Salvadori; Claudio Trapella; Rainer K Reinscheid; Girolamo Calo; Remo Guerrini
Journal:  Pharmacol Res Perspect       Date:  2015-01-05

10.  Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies.

Authors:  Chiara Ruzza; Federica Ferrari; Remo Guerrini; Erika Marzola; Delia Preti; Rainer K Reinscheid; Girolamo Calo
Journal:  Pharmacol Res Perspect       Date:  2018-12-03
  10 in total

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