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Literature DB >> 19465932

Identification of the toxic trigger in mushroom poisoning.

Masanori Matsuura¹, Yoko Saikawa, Kosei Inui, Koichi Nakae, Masayuki Igarashi, Kimiko Hashimoto, Masaya Nakata.

Abstract

We have isolated the small, highly strained carboxylic acid cycloprop-2-ene carboxylic acid from the Asian toxic mushroom Russula subnigricans. This compound is responsible for fatal rhabdomyolysis, a new type of mushroom poisoning that is indicated by an increase in serum creatine phosphokinase activity in mice. We found that polymerization of the compound at high concentrations via ene reaction abolishes its toxicity.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2009 PMID： 19465932 DOI： 10.1038/nchembio.179

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

10 in total

1. Wild-mushroom intoxication as a cause of rhabdomyolysis.

Authors: R Bedry; I Baudrimont; G Deffieux; E E Creppy; J P Pomies; J M Ragnaud; M Dupon; D Neau; C Gabinski; S De Witte; J C Chapalain; P Godeau; J Beylot
Journal: N Engl J Med Date: 2001-09-13 Impact factor: 91.245

2. Russuphelin A, a new cytotoxic substance from the mushroom Russula subnigricans Hongo.

Authors: A Takahashi; T Agatsuma; M Matsuda; T Ohta; T Nunozawa; T Endo; S Nozoe
Journal: Chem Pharm Bull (Tokyo) Date: 1992-12 Impact factor: 1.645

3. Russuphelins B, C, D, E and F, new cytotoxic substances from the mushroom Russula subnigricans Hongo.

Authors: A Takahashi; T Agatsuma; T Ohta; T Nunozawa; T Endo; S Nozoe
Journal: Chem Pharm Bull (Tokyo) Date: 1993-10 Impact factor: 1.645

4. Rhabdomyolysis: an unusual feature with mushroom poisoning.

Authors: P T Lee; M L Wu; W J Tsai; J Ger; J F Deng; H M Chung
Journal: Am J Kidney Dis Date: 2001-10 Impact factor: 8.860

5. Rhabdomyolysis and acute renal failure induced by paraphenylenediamine.

Authors: Z Averbukh; D Modai; Y Leonov; J Weissgarten; G Lewinsohn; L Fucs; A Golik; E Rosenmann
Journal: Hum Toxicol Date: 1989-09

6. Suspected myotoxicity of edible wild mushrooms.

Authors: Petteri Nieminen; Markku Kirsi; Anne-Mari Mustonen
Journal: Exp Biol Med (Maywood) Date: 2006-02

7. Synthesis of stable derivatives of cycloprop-2-ene carboxylic acid.

Authors: Ni Yan; Xiaozhong Liu; Mahesh K Pallerla; Joseph M Fox
Journal: J Org Chem Date: 2008-05-02 Impact factor: 4.354

8. Myo- and hepatotoxic effects of cultivated mushrooms in mice.

Authors: Petteri Nieminen; Vesa Kärjä; Anne-Mari Mustonen
Journal: Food Chem Toxicol Date: 2008-10-14 Impact factor: 6.023

9. Acute poisoning with Tricholoma equestre.

Authors: Zygmunt Chodorowski; Wojciech Waldman; Jacek Sein Anand
Journal: Przegl Lek Date: 2002

10. Indications of hepatic and cardiac toxicity caused by subchronic Tricholoma flavovirens consumption.

Authors: P Nieminen; V Kärjä; A-M Mustonen
Journal: Food Chem Toxicol Date: 2007-10-25 Impact factor: 6.023

10 in total

17 in total

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Journal: ACS Chem Biol Date: 2019-12-05 Impact factor: 5.100

Review 2. Mycetism: a review of the recent literature.

Authors: Kimberlie A Graeme
Journal: J Med Toxicol Date: 2014-06

Review 3. Update on toxic myopathies.

Authors: F L Mastaglia; M Needham
Journal: Curr Neurol Neurosci Rep Date: 2012-02 Impact factor: 5.081

Review 4. Mushroom Poisoning.

Authors: Robert Wennig; Florian Eyer; Andreas Schaper; Thomas Zilker; Hilke Andresen-Streichert
Journal: Dtsch Arztebl Int Date: 2020-10-16 Impact factor: 5.594