Literature DB >> 19464171

Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.

Richard V Connors1, Zhulun Wang, Martin Harrison, Alex Zhang, Malgorzata Wanska, Steve Hiscock, Brian Fox, Michael Dore, Marc Labelle, Athena Sudom, Sheree Johnstone, Jinsong Liu, Nigel P C Walker, Anne Chai, Karen Siegler, Yang Li, Peter Coward.   

Abstract

The discovery and optimization of a series of potent PPARdelta full agonists with partial agonistic activity against PPARgamma is described.

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Year:  2009        PMID： 19464171     DOI： 10.1016/j.bmcl.2009.04.151

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

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9.  Structure-based virtual screening and discovery of New PPARδ/γ dual agonist and PPARδ and γ agonists.

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