Literature DB >> 1946393

Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes.

C V Jongeneel1, L Briant, I A Udalova, A Sevin, S A Nedospasov, A Cambon-Thomsen.   

Abstract

We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-beta gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-beta gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies.

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Year:  1991        PMID： 1946393      PMCID： PMC52790          DOI： 10.1073/pnas.88.21.9717

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

1.  Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis.

Authors:  I Dunham; C A Sargent; J Trowsdale; R D Campbell
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

2.  Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.

Authors:  M C Carroll; P Katzman; E M Alicot; B H Koller; D E Geraghty; H T Orr; J L Strominger; T Spies
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

3.  Tumour necrosis factor and lymphotoxin genes map close to H-2D in the mouse major histocompatibility complex.

Authors:  U Müller; C V Jongeneel; S A Nedospasov; K F Lindahl; M Steinmetz
Journal:  Nature       Date:  1987 Jan 15-21       Impact factor: 49.962

4.  Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

Authors:  T Spies; C C Morton; S A Nedospasov; W Fiers; D Pious; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

5.  A new BF variant (BF S11) with information for orientation of MHC class III genes.

Authors:  M Abbal; C Moennarid; A Cambon-Thomsen; J Tkaczuk; E Ohayon; G Mauff
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

6.  HLA class II induction in human islet cells by interferon-gamma plus tumour necrosis factor or lymphotoxin.

Authors:  R Pujol-Borrell; I Todd; M Doshi; G F Bottazzo; R Sutton; D Gray; G R Adolf; M Feldmann
Journal:  Nature       Date:  1987 Mar 19-25       Impact factor: 49.962

7.  HLA-A, B, C, DR antigens, Bf, C4 and glyoxalase I (GLO) polymorphisms in French Basques with insulin-dependent diabetes mellitus (IDDM).

Authors:  A Cambon-de Mouzon; E Ohayon; G Hauptmann; A Sevin; M Abbal; E Sommer; H Vergnes; J Ducos
Journal:  Tissue Antigens       Date:  1982-05

8.  Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome.

Authors:  S A Nedospasov; A N Shakhov; R L Turetskaya; V A Mett; M M Azizov; G P Georgiev; V G Korobko; V N Dobrynin; S A Filippov; N S Bystrov
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1986

9.  The susceptibility to insulin-dependent diabetes mellitus is associated with C4 allotypes independently of the association with HLA-DQ alleles in HLA-DR3,4 heterozygotes.

Authors:  M Thomsen; J Mølvig; A Zerbib; C de Preval; M Abbal; J M Dugoujon; E Ohayon; A Svejgaard; A Cambon-Thomsen; J Nerup
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

10.  DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.

Authors:  S A Nedospasov; I A Udalova; D V Kuprash; R L Turetskaya
Journal:  J Immunol       Date:  1991-08-01       Impact factor: 5.422
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  30 in total

Review 1.  Tumour necrosis factor gene polymorphisms as severity markers in rheumatoid arthritis.

Authors:  C L Verweij
Journal:  Ann Rheum Dis       Date:  1999-11       Impact factor: 19.103

2.  High-density map of short tandem repeats across the human major histocompatibility complex.

Authors:  Michael Cullen; Michael Malasky; Anita Harding; Mary Carrington
Journal:  Immunogenetics       Date:  2003-02-21       Impact factor: 2.846

3.  Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasia.

Authors:  Claire Vandiedonck; Geneviève Beaurain; Matthieu Giraud; Catherine Hue-Beauvais; Bruno Eymard; Christine Tranchant; Philippe Gajdos; Jean Dausset; Henri-Jean Garchon
Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-15       Impact factor: 11.205

4.  Analysis of the contribution of HLA genes to genetic predisposition in inflammatory bowel disease.

Authors:  I Naom; J Lee; D Ford; S J Bowman; J S Lanchbury; I Haris; S V Hodgson; D Easton; J Lennard-Jones; C G Mathew
Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

5.  Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population.

Authors:  K van der Weide; H Loovers; K Pondman; J Bogers; T van der Straaten; E Langemeijer; D Cohen; J Commandeur; J van der Weide
Journal:  Pharmacogenomics J       Date:  2016-05-10       Impact factor: 3.550

6.  Linkage and association of the HLA gene complex with IDDM in 81 Danish families: strong linkage between DR beta 1Lys71+ and IDDM.

Authors:  M Zamani; F Pociot; M Spaepen; P Raeymaekers; J Nerup; J J Cassiman
Journal:  J Med Genet       Date:  1996-11       Impact factor: 6.318

7.  Novel compound tetra-, dinucleotide microsatellite polymorphism in the tumor necrosis factor/lymphotoxin locus.

Authors:  S J Greenberg; K Fujihara; S M Selkirk; F Yu; T L Du; N Glenister; P Hohmann; M H Rickert; P O Spence; C E Miller; L D Jacobs
Journal:  Clin Diagn Lab Immunol       Date:  1997-01

8.  TNFalpha*2 marks high risk of severe disease during Plasmodium falciparum malaria and other infections in Sri Lankans.

Authors:  J Wattavidanage; R Carter; K L Perera; A Munasingha; S Bandara; D McGuinness; A R Wickramasinghe; H K Alles; K N Mendis; S Premawansa
Journal:  Clin Exp Immunol       Date:  1999-02       Impact factor: 4.330

9.  Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass.

Authors:  A Roth-Isigkeit; L Hasselbach; E Ocklitz; S Brückner; A Ros; H Gehring; P Schmucker; L Rink; M Seyfarth
Journal:  Clin Exp Immunol       Date:  2001-07       Impact factor: 4.330

10.  A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group.

Authors:  M Fennessy; K Metcalfe; G A Hitman; M Niven; P A Biro; J Tuomilehto; E Tuomilehto-Wolf
Journal:  Diabetologia       Date:  1994-09       Impact factor: 10.122
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