| Literature DB >> 19463715 |
Edward C Holmes1, Phaik-Hooi Tio, David Perera, Jamail Muhi, Jane Cardosa.
Abstract
Although dengue is a common disease in South-East Asia, there is a marked absence of virological data from the Malaysian state of Sarawak located on the island of Borneo. From 1997 to 2002 we noted the co-circulation of DENV-2, DENV-3 and DENV-4 in Sarawak. To determine the origins of these Sarawak viruses we obtained the complete E gene sequences of 21 isolates. A phylogenetic analysis revealed multiple entries of DENV-2 and DENV-4 into Sarawak, such that multiple lineages co-circulate, yet with little exportation from Sarawak. Notably, all viral isolates were most closely related to those circulating in different localities in South-East Asia. In sum, our analysis reveals a frequent traffic of DENV in South-East Asia, with Sarawak representing a local sink population.Entities:
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Year: 2009 PMID： 19463715 DOI： 10.1016/j.virusres.2009.02.020
Source DB: PubMed Journal: Virus Res ISSN： 0168-1702 Impact factor: 3.303