BACKGROUND AND PURPOSE: Differences between women and men in relation to stroke are increasingly being recognized. METHODS: From July 2004 until June 2007, 237 acute ischemic stroke (AIS) patients were treated with recombinant tissue plasminogen activator (rtPA) within 3 hours after onset of symptoms in our stroke unit. Baseline characteristics, etiology, CT/MRI stroke patterns, clinical outcome, and complications of women were compared to those of men. RESULTS: Of 237 AIS patients (mean age 70.7 years), 111 (46.8%) were women and 126 (53.2%) were men. Women were older (P=0.001), but history of hyperlipidemia (P=0.03), smoking (P=0.03), and coronary heart disease (P<0.001) was less frequent than in men. Internal carotid artery disease occurred more often in men (P=0.02), whereas atrial fibrillation was observed more often in women (P=0.002). In men borderzone/small embolic and lacunar stroke was found more frequently (39.7 versus 27.2%), whereas women showed a higher percentage of large territorial stroke (72.8 versus 60.3%, P=0.09). Baseline National Institute of Health Stroke Scale scores (12.5 versus 11.3), NIHSS score at discharge (11.0 versus 9.5), 3-month-outcome modified Rankin Scale score, thrombolysis-related (17.1% versus 13.5%) or independent complications (32.4% versus 30.2%), and mortality after 3 months (13.5% versus 9.5%) were similar. CONCLUSIONS: Differences of stroke lesion patterns in genders are paralleled by differences in etiology and risk factor profiles (women, cardioembolism; men, large and small vessel disease). Baseline characteristics, rates of rtPA-related and independent complications, as well as clinical outcomes were not different between women and men with AIS.
BACKGROUND AND PURPOSE: Differences between women and men in relation to stroke are increasingly being recognized. METHODS: From July 2004 until June 2007, 237 acute ischemic stroke (AIS) patients were treated with recombinant tissue plasminogen activator (rtPA) within 3 hours after onset of symptoms in our stroke unit. Baseline characteristics, etiology, CT/MRI stroke patterns, clinical outcome, and complications of women were compared to those of men. RESULTS: Of 237 AIS patients (mean age 70.7 years), 111 (46.8%) were women and 126 (53.2%) were men. Women were older (P=0.001), but history of hyperlipidemia (P=0.03), smoking (P=0.03), and coronary heart disease (P<0.001) was less frequent than in men. Internal carotid artery disease occurred more often in men (P=0.02), whereas atrial fibrillation was observed more often in women (P=0.002). In men borderzone/small embolic and lacunar stroke was found more frequently (39.7 versus 27.2%), whereas women showed a higher percentage of large territorial stroke (72.8 versus 60.3%, P=0.09). Baseline National Institute of Health Stroke Scale scores (12.5 versus 11.3), NIHSS score at discharge (11.0 versus 9.5), 3-month-outcome modified Rankin Scale score, thrombolysis-related (17.1% versus 13.5%) or independent complications (32.4% versus 30.2%), and mortality after 3 months (13.5% versus 9.5%) were similar. CONCLUSIONS: Differences of stroke lesion patterns in genders are paralleled by differences in etiology and risk factor profiles (women, cardioembolism; men, large and small vessel disease). Baseline characteristics, rates of rtPA-related and independent complications, as well as clinical outcomes were not different between women and men with AIS.
Authors: Caroline E McCoach; Ehrin J Armstrong; Satinder Singh; Usman Javed; David Anderson; Khung Keong Yeo; Gregory G Westin; Nasim Hedayati; Ezra A Amsterdam; John R Laird Journal: Vasc Med Date: 2013-02 Impact factor: 3.239
Authors: Yingfang Tian; Boryana Stamova; Glen C Jickling; Huichun Xu; Dazhi Liu; Bradley P Ander; Cheryl Bushnell; Xinhua Zhan; Renee J Turner; Ryan R Davis; Piero Verro; William C Pevec; Nasim Hedayati; David L Dawson; Jane Khoury; Edward C Jauch; Arthur Pancioli; Joseph P Broderick; Frank R Sharp Journal: Gend Med Date: 2012-02-24
Authors: Boryana Stamova; Yingfang Tian; Glen Jickling; Cheryl Bushnell; Xinhua Zhan; Dazhi Liu; Bradley P Ander; Piero Verro; Vihar Patel; William C Pevec; Nasim Hedayati; David L Dawson; Edward C Jauch; Arthur Pancioli; Joseph P Broderick; Frank R Sharp Journal: Stroke Date: 2011-11-03 Impact factor: 7.914
Authors: Gisele S Silva; Fabricio O Lima; Erica C S Camargo; Wade S Smith; Michael H Lev; Gordon J Harris; Elkan F Halpern; Walter Koroshetz; Karen L Furie Journal: Cerebrovasc Dis Date: 2010-08-24 Impact factor: 2.762
Authors: Liyong Wang; Danielle Yanuck; Ashley Beecham; Hannah Gardener; Susan Slifer; Susan H Blanton; Ralph L Sacco; Tatjana Rundek Journal: Stroke Date: 2011-01-21 Impact factor: 7.914