Literature DB >> 19458396

Optobionic vision--a new genetically enhanced light on retinal prosthesis.

Patrick Degenaar1, Nir Grossman, Muhammad Ali Memon, Juan Burrone, Martin Dawson, Emmanuel Drakakis, Mark Neil, Konstantin Nikolic.   

Abstract

The recent discovery that neurons can be photostimulated via genetic incorporation of artificial opsins is creating a revolution in the field of neural stimulation. In this paper we show its potential in the field of retinal prosthesis. We show that we need typically 100 mW cm(-2) in instantaneous light intensity on the neuron in order to stimulate action potentials. We also show how this can be reduced down to safe levels in order to negate thermal and photochromic damage to the eye. We also describe a gallium nitride LED light source which is also able to generate patterns of the required intensity in order to transfer reliable images.

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Year:  2009        PMID: 19458396     DOI: 10.1088/1741-2560/6/3/035007

Source DB:  PubMed          Journal:  J Neural Eng        ISSN: 1741-2552            Impact factor:   5.379


  24 in total

Review 1.  Evolution of optogenetic microdevices.

Authors:  Rajas P Kale; Abbas Z Kouzani; Ken Walder; Michael Berk; Susannah J Tye
Journal:  Neurophotonics       Date:  2015-06-25       Impact factor: 3.593

2.  Restoring vision in mice with retinal degeneration using multicharacteristic opsin.

Authors:  Weldon Wright; Sivakumar Gajjeraman; Subrata Batabyal; Sanjay Pradhan; Sulagna Bhattacharya; Vasu Mahapatra; Ashutosh Tripathy; Samarendra Mohanty
Journal:  Neurophotonics       Date:  2017-08-18       Impact factor: 3.593

3.  A system for optically controlling neural circuits with very high spatial and temporal resolution.

Authors:  Chethan Pandarinath; Eric T Carlson; Sheila Nirenberg
Journal:  Proc IEEE Int Symp Bioinformatics Bioeng       Date:  2013-11

4.  A bio-inspired glucose controller based on pancreatic β-cell physiology.

Authors:  Pau Herrero; Pantelis Georgiou; Nick Oliver; Desmond G Johnston; Christofer Toumazou
Journal:  J Diabetes Sci Technol       Date:  2012-05-01

5.  A hybrid bioorganic interface for neuronal photoactivation.

Authors:  Diego Ghezzi; Maria Rosa Antognazza; Marco Dal Maschio; Erica Lanzarini; Fabio Benfenati; Guglielmo Lanzani
Journal:  Nat Commun       Date:  2011-01-25       Impact factor: 14.919

6.  Photochemical restoration of visual responses in blind mice.

Authors:  Aleksandra Polosukhina; Jeffrey Litt; Ivan Tochitsky; Joseph Nemargut; Yivgeny Sychev; Ivan De Kouchkovsky; Tracy Huang; Katharine Borges; Dirk Trauner; Russell N Van Gelder; Richard H Kramer
Journal:  Neuron       Date:  2012-07-26       Impact factor: 17.173

7.  Improved content aware scene retargeting for retinitis pigmentosa patients.

Authors:  Walid I Al-Atabany; Tzyy Tong; Patrick A Degenaar
Journal:  Biomed Eng Online       Date:  2010-09-16       Impact factor: 2.819

8.  Designing and testing scene enhancement algorithms for patients with retina degenerative disorders.

Authors:  Walid I Al-Atabany; Muhammad A Memon; Susan M Downes; Patrick A Degenaar
Journal:  Biomed Eng Online       Date:  2010-06-18       Impact factor: 2.819

9.  The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials.

Authors:  Nir Grossman; Vasiliki Simiaki; Claire Martinet; Christofer Toumazou; Simon R Schultz; Konstantin Nikolic
Journal:  J Comput Neurosci       Date:  2012-11-22       Impact factor: 1.621

10.  Infrared neural stimulation in the cochlea.

Authors:  Claus-Peter Richter; Suhrud Rajguru; Mark Bendett
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2013-03-08
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