Literature DB >> 19457561

IL-17 potentiates neuronal injury induced by oxygen-glucose deprivation and affects neuronal IL-17 receptor expression.

Dan-dan Wang1, Yan-feng Zhao, Guang-you Wang, Bo Sun, Qing-fei Kong, Kai Zhao, Yao Zhang, Jing-hua Wang, Yu-mei Liu, Li-li Mu, De-sheng Wang, Hu-lun Li.   

Abstract

Interleukin-17 (IL-17) is active in a variety of brain injuries, including ischemia. The objective of this study was to test the hypothesis that IL-17 potentiates neuronal injury after stroke. Increased expression of IL-17 and IL-17 receptor (IL-17R) in serum and cortex was evaluated by ELISA, RT-PCR and immunohistochemistry. In the in vitro model of oxygen-glucose deprivation (OGD), IL-17 showed a dose-dependent effect in promoting neuronal injury through IL-17-IL-17R combination which can be blocked by IL-17R/Fc chimera. Our results demonstrated the up-regulation of IL-17 and IL-17R following permanent middle cerebral artery occlusion and suggested that they contributed to stroke outcome.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19457561     DOI： 10.1016/j.jneuroim.2009.04.007

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  26 in total

1.  Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis.

Authors:  Kirsten A Kulcsar; Victoria K Baxter; Ivorlyne P Greene; Diane E Griffin
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-31       Impact factor: 11.205

Review 2.  IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease.

Authors:  Jarod Zepp; Ling Wu; Xiaoxia Li
Journal:  Trends Immunol       Date:  2011-04-12       Impact factor: 16.687

Review 3.  The IL-17 family cytokines in immunity and disease.

Authors:  Rajita Pappu; Vladimir Ramirez-Carrozzi; Naruhisa Ota; Wenjun Ouyang; Yan Hu
Journal:  J Clin Immunol       Date:  2010-02-23       Impact factor: 8.317

4.  Neutralization of IL-17 rescues amyloid-β-induced neuroinflammation and memory impairment.

Authors:  Claudia Cristiano; Floriana Volpicelli; Pellegrino Lippiello; Benedetta Buono; Federica Raucci; Marialuisa Piccolo; Asif Jilani Iqbal; Carlo Irace; Maria Concetta Miniaci; Carla Perrone Capano; Antonio Calignano; Nicola Mascolo; Francesco Maione
Journal:  Br J Pharmacol       Date:  2019-03-03       Impact factor: 8.739

Review 5.  Chorioamnionitis, IL-17A, and fetal origins of neurologic disease.

Authors:  Shelley M Lawrence; James L Wynn
Journal:  Am J Reprod Immunol       Date:  2017-12-22       Impact factor: 3.886

6.  Hypothermia Reduces but Hyperthermia Augments T Cell-Derived Release of Interleukin-17 and Granzyme B that Mediate Neuronal Cell Death.

Authors:  Tomohiro Matsui; Natsumi Kawahara; Arisa Kimoto; Yusuke Yoshida
Journal:  Neurocrit Care       Date:  2015-08       Impact factor: 3.210

7.  Glia maturation factor deficiency suppresses 1-methyl-4-phenylpyridinium-induced oxidative stress in astrocytes.

Authors:  Mohammad Moshahid Khan; Duraisamy Kempuraj; Smita Zaheer; Asgar Zaheer
Journal:  J Mol Neurosci       Date:  2014-01-16       Impact factor: 3.444

8.  Interleukin-22 protects rat PC12 pheochromocytoma cells from serum deprivation-induced cell death.

Authors:  Yongchun Liu; Wenyan Pan; Shengmei Yang; Xiaoying Wu; Jianfu Wu; Jun Ma; Zengqiang Yuan; Songshu Meng
Journal:  Mol Cell Biochem       Date:  2012-09-16       Impact factor: 3.396

Review 9.  IL-17 in neonatal health and disease.

Authors:  Shelley M Lawrence; Jessica Lauren Ruoss; James L Wynn
Journal:  Am J Reprod Immunol       Date:  2017-12-15       Impact factor: 3.886

Review 10.  Alphavirus Encephalomyelitis: Mechanisms and Approaches to Prevention of Neuronal Damage.

Authors:  Diane E Griffin
Journal:  Neurotherapeutics       Date:  2016-07       Impact factor: 7.620
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.