Literature DB >> 19455427

Assessment of feasibility of maillard reaction between baclofen and lactose by liquid chromatography and tandem mass spectrometry, application to pre formulation studies.

Farnaz Monajjemzadeh1, Davoud Hassanzadeh, Hadi Valizadeh, Mohammad R Siahi-Shadbad, Javid Shahbazi Mojarrad, Thomas Robertson, Michael S Roberts.   

Abstract

The aim of this study was to determine any possible, baclofen-lactose Maillard reaction products. Granules and tablets of baclofen and lactose were prepared and maintained in heat ovens for a certain time period. The effects of lactose type, addition of magnesium stearate, and water were monitored. Heated lactose and baclofen were analyzed using reverse-phase HPLC. Liquid chromatography tandem mass spectroscopy revealed nominal mass values consistent with baclofen-lactose, early-stage Maillard reaction condensation products (ESMRP). Multiple reaction monitoring confirmed the presence of ESMRP as well. FTIR analysis proved the formation of imine bond. The results indicated that baclofen undergoes a Maillard-type reaction with lactose.

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Year:  2009        PMID： 19455427      PMCID： PMC2690811          DOI： 10.1208/s12249-009-9248-8

Source DB:  PubMed          Journal:  AAPS PharmSciTech        ISSN： 1530-9932            Impact factor:   3.246


  22 in total

1.  The early glycation products of the Maillard reaction: mass spectrometric characterization of novel imidazolidinones derived from an opioid pentapeptide and glucose.

Authors:  M Roscić; C Versluis; A J Kleinnijenhuis; S Horvat; A J Heck
Journal:  Rapid Commun Mass Spectrom       Date:  2001       Impact factor: 2.419

Review 2.  Chemistry of Amadori rearrangement products: analysis, synthesis, kinetics, reactions, and spectroscopic properties.

Authors:  V A Yaylayan; A Huyghues-Despointes
Journal:  Crit Rev Food Sci Nutr       Date:  1994       Impact factor: 11.176

Review 3.  The Maillard reaction in food; a critical review from the nutritional standpoint.

Authors:  J Mauron
Journal:  Prog Food Nutr Sci       Date:  1981

4.  Liquid chromatography-mass spectrometry and proton nuclear magnetic resonance characterization of trace level condensation products formed between lactose and the amine-containing diuretic hydrochlorothiazide.

Authors:  P A Harmon; W Yin; W E Bowen; R J Tyrrell; R A Reed
Journal:  J Pharm Sci       Date:  2000-07       Impact factor: 3.534

5.  Reaction of folic acid with reducing sugars and sugar degradation products.

Authors:  Marc Schneider; Marcus Klotzsche; Christoph Werzinger; Jörg Hegele; Reiner Waibel; Monika Pischetsrieder
Journal:  J Agric Food Chem       Date:  2002-03-13       Impact factor: 5.279

6.  Monitoring carbonyl-amine reaction between pyruvic acid and alpha-amino alcohols by FTIR spectroscopy--a possible route to Amadori products.

Authors:  Andrzej Wnorowski; Varoujan A Yaylayan
Journal:  J Agric Food Chem       Date:  2003-10-22       Impact factor: 5.279

7.  Amlodipine besylate-excipients interaction in solid dosage form.

Authors:  A Abdoh; M M Al-Omari; A A Badwan; A M Y Jaber
Journal:  Pharm Dev Technol       Date:  2004       Impact factor: 3.133

8.  Compaction of crystallographic forms of pharmaceutical granular lactoses. II. Compacts mechanical properties.

Authors:  Virginie Busignies; Pierre Tchoreloff; Bernard Leclerc; Christine Hersen; Gérard Keller; Guy Couarraze
Journal:  Eur J Pharm Biopharm       Date:  2004-11       Impact factor: 5.571

9.  Compaction of crystallographic forms of pharmaceutical granular lactoses. I. Compressibility.

Authors:  V Busignies; P Tchoreloff; B Leclerc; M Besnard; G Couarraze
Journal:  Eur J Pharm Biopharm       Date:  2004-11       Impact factor: 5.571

10.  In silico assessment of toxicity of heat-generated food contaminants.

Authors:  J V Cotterill; M Q Chaudhry; W Matthews; R W Watkins
Journal:  Food Chem Toxicol       Date:  2008-01-26       Impact factor: 6.023
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  4 in total

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Journal:  Pharm Res       Date:  2012-06-16       Impact factor: 4.200

2.  Synthesis and Characterization of Maillard Reaction Products of Salbutamol and Terbutaline with Lactose and Development and Validation of an LC Method for the Determination of Salbutamol and Terbutaline in the Presence of These Impurities.

Authors:  Asmaa A El-Zaher; Marwa A Fouad; Ehab F Elkady
Journal:  Anal Chem Insights       Date:  2014-03-02

3.  Thermal Stability and Kinetic Study of Fluvoxamine Stability in Binary Samples with Lactose.

Authors:  Faranak Ghaderi; Mahboob Nemati; Mohammad Reza Siahi-Shadbad; Hadi Valizadeh; Farnaz Monajjemzadeh
Journal:  Adv Pharm Bull       Date:  2017-04-13

4.  Physicochemical analysis and nonisothermal kinetic study of sertraline-lactose binary mixtures.

Authors:  Faranak Ghaderi; Mahboob Nemati; Mohammad Reza Siahi-Shadbad; Hadi Valizadeh; Farnaz Monajjemzadeh
Journal:  J Food Drug Anal       Date:  2016-11-03       Impact factor: 6.157
  4 in total

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