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Literature DB >> 19454283

Posttranscriptional down-regulation of small ribosomal subunit proteins correlates with reduction of 18S rRNA in RPS19 deficiency.

Jitendra Badhai¹, Anne-Sophie Fröjmark, Hamid Reza Razzaghian, Edward Davey, Jens Schuster, Niklas Dahl.

Abstract

Ribosomal protein S19 (RPS19) is mutated in patients with Diamond-Blackfan anemia (DBA). We hypothesized that decreased levels of RPS19 lead to a coordinated down-regulation of other ribosomal (r-)proteins at the subunit level. We show that small interfering RNA (siRNA) knock-down of RPS19 results in a relative decrease of small subunit (SSU) r-proteins (S20, S21 and S24) when compared to large subunit (LSU) r-proteins (L3, L9, L30 and L38). This correlates with a relative decrease in 18S rRNA with respect to 28S rRNA. The r-protein mRNA levels remain relatively unchanged indicating a post transcriptional regulation of r-proteins at the level of subunit formation.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

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Year: 2009 PMID： 19454283 PMCID： PMC2737615 DOI： 10.1016/j.febslet.2009.05.023

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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