INTRODUCTION: Although patients with end-stage organ failure are at high risk for vitamin D deficiency because of limited sunlight exposure and hepatic dysfunction, few studies have measured 25-hydroxy vitamin D (25OHD) at the time of transplantation. METHODS: We measured serum 25OHD immediately after transplantation in 69 heart and liver transplant recipients. RESULTS:Forty-six heart and 23 liver transplant recipients were evaluated (mean age 53 yr). Mean 25OHD was well below the lower limit of the normal range (43.2 +/- 21.2 nmol/L). Ninety-one percent had levels below 75 nmol/L, the threshold commonly used to denote sufficiency, and 71% had levels below 50 nmol/L. Severe deficiency (25OHD <25 nmol/L) was found in 16%. Vitamin D levels did not differ by race, age, gender, or season. Mean 25OHD was lower among liver than heart transplant recipients (34.4 +/- 17.5 vs. 47.7 +/- 20.7 nmol/L; p < 0.03). Among liver transplant recipients, 22% had undetectable levels (<17 nmol/L). CONCLUSIONS: Vitamin D deficiency is highly prevalent among heart and liver transplant recipients; those with liver failure are at greatest risk. As vitamin D deficiency has many serious skeletal and extra-skeletal sequelae, physicians who treat transplant patients should maintain a high degree of vigilance for this problem.
RCT Entities:
INTRODUCTION: Although patients with end-stage organ failure are at high risk for vitamin D deficiency because of limited sunlight exposure and hepatic dysfunction, few studies have measured 25-hydroxy vitamin D (25OHD) at the time of transplantation. METHODS: We measured serum 25OHD immediately after transplantation in 69 heart and liver transplant recipients. RESULTS: Forty-six heart and 23 liver transplant recipients were evaluated (mean age 53 yr). Mean 25OHD was well below the lower limit of the normal range (43.2 +/- 21.2 nmol/L). Ninety-one percent had levels below 75 nmol/L, the threshold commonly used to denote sufficiency, and 71% had levels below 50 nmol/L. Severe deficiency (25OHD <25 nmol/L) was found in 16%. Vitamin D levels did not differ by race, age, gender, or season. Mean 25OHD was lower among liver than heart transplant recipients (34.4 +/- 17.5 vs. 47.7 +/- 20.7 nmol/L; p < 0.03). Among liver transplant recipients, 22% had undetectable levels (<17 nmol/L). CONCLUSIONS:Vitamin D deficiency is highly prevalent among heart and liver transplant recipients; those with liver failure are at greatest risk. As vitamin D deficiency has many serious skeletal and extra-skeletal sequelae, physicians who treat transplant patients should maintain a high degree of vigilance for this problem.
Authors: Bryan N Becker; Debra A Hullett; Jacquelyn K O'Herrin; Gretchen Malin; Hans W Sollinger; Hector DeLuca Journal: Transplantation Date: 2002-10-27 Impact factor: 4.939
Authors: N Binkley; D Krueger; C S Cowgill; L Plum; E Lake; K E Hansen; H F DeLuca; M K Drezner Journal: J Clin Endocrinol Metab Date: 2004-07 Impact factor: 5.958
Authors: A Monegal; M Navasa; N Guañabens; P Peris; F Pons; M J Martinez de Osaba; J Ordi; A Rimola; J Rodés; J Muñoz-Gómez Journal: Osteoporos Int Date: 2001 Impact factor: 4.507
Authors: Elizabeth Shane; Vicki Addesso; Pearila B Namerow; Donald J McMahon; Shaw-Hwa Lo; Ronald B Staron; Mark Zucker; Susan Pardi; Simon Maybaum; Donna Mancini Journal: N Engl J Med Date: 2004-02-19 Impact factor: 91.245
Authors: Paul Glendenning; Jane M Noble; Mario Taranto; Alexander A Musk; Marjory McGuiness; Peter R Goldswain; William D Fraser; Samuel D Vasikaran Journal: Ann Clin Biochem Date: 2003-09 Impact factor: 2.057
Authors: Elizabeth Shane; Adi Cohen; Emily M Stein; Donald J McMahon; Chiyuan Zhang; Polly Young; Kavita Pandit; Ronald B Staron; Elizabeth C Verna; Robert Brown; Susan Restaino; Donna Mancini Journal: J Clin Endocrinol Metab Date: 2012-09-28 Impact factor: 5.958
Authors: Peter P Reese; Roy D Bloom; Harold I Feldman; Ari Huverserian; Arwin Thomasson; Justine Shults; Takayuki Hamano; Simin Goral; Abraham Shaked; Kimberly Olthoff; Michael R Rickels; Melissa Bleicher; Mary B Leonard Journal: Liver Int Date: 2011-09-09 Impact factor: 5.828