Hanel Sadie-Van Gijsen1. 1. Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University Tygerberg Campus, Francie van Zijl Drive, PO Box 241, Parow, Cape Town, 8000, South Africa. hsadie@sun.ac.za.
Abstract
PURPOSE OF REVIEW: To review the available literature regarding a possible relationship between vitamin D and bone marrow adipose tissue (BMAT), and to identify future avenues of research that warrant attention. RECENT FINDINGS: Results from in vivo animal and human studies all support the hypothesis that vitamin D can suppress BMAT expansion. This is achieved by antagonizing adipogenesis in bone marrow stromal cells, through inhibition of PPARγ2 activity and stimulation of pro-osteogenic Wnt signalling. However, our understanding of the functions of BMAT is still evolving, and studies on the role of vitamin D in modulating BMAT function are lacking. In addition, many diseases and chronic conditions are associated with low vitamin D status and low bone mineral density (BMD), but BMAT expansion has not been studied in these patient populations. Vitamin D suppresses BMAT expansion, but its role in modulating BMAT function is poorly understood.
PURPOSE OF REVIEW: To review the available literature regarding a possible relationship between vitamin D and bone marrow adipose tissue (BMAT), and to identify future avenues of research that warrant attention. RECENT FINDINGS: Results from in vivo animal and human studies all support the hypothesis that vitamin D can suppress BMAT expansion. This is achieved by antagonizing adipogenesis in bone marrow stromal cells, through inhibition of PPARγ2 activity and stimulation of pro-osteogenic Wnt signalling. However, our understanding of the functions of BMAT is still evolving, and studies on the role of vitamin D in modulating BMAT function are lacking. In addition, many diseases and chronic conditions are associated with low vitamin D status and low bone mineral density (BMD), but BMAT expansion has not been studied in these patient populations. Vitamin D suppresses BMAT expansion, but its role in modulating BMAT function is poorly understood.
Entities:
Keywords:
Bone marrow fat; Bone mineral density; Marrow fat unsaturation; PPARγ2; Vitamin D
Authors: Tiffany Y Kim; Ann V Schwartz; Xiaojuan Li; Kaipin Xu; Dennis M Black; Dimitry M Petrenko; Lygia Stewart; Stanley J Rogers; Andrew M Posselt; Jonathan T Carter; Dolores M Shoback; Anne L Schafer Journal: J Bone Miner Res Date: 2017-08-09 Impact factor: 6.741
Authors: Frans Alexander Jacobs; Hanél Sadie-Van Gijsen; Mari van de Vyver; William Frank Ferris Journal: Front Endocrinol (Lausanne) Date: 2016-08-03 Impact factor: 5.555