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Literature DB >> 19453251

The posttranslational processing of prelamin A and disease.

Brandon S J Davies¹, Loren G Fong, Shao H Yang, Catherine Coffinier, Stephen G Young.

Abstract

Human geneticists have shown that some progeroid syndromes are caused by mutations that interfere with the conversion of farnesyl-prelamin A to mature lamin A. For example, Hutchinson-Gilford progeria syndrome is caused by LMNA mutations that lead to the accumulation of a farnesylated version of prelamin A. In this review, we discuss the posttranslational modifications of prelamin A and their relevance to the pathogenesis and treatment of progeroid syndromes.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2009 PMID： 19453251 PMCID： PMC2846822 DOI： 10.1146/annurev-genom-082908-150150

Source DB: PubMed Journal: Annu Rev Genomics Hum Genet ISSN： 1527-8204 Impact factor: 8.929

118 in total

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2. Hutchinson-Gilford progeria syndrome: a pathologic study.

Authors: Jeanne Ackerman; Enid Gilbert-Barness
Journal: Pediatr Pathol Mol Med Date: 2002 Jan-Feb

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Authors: Annachiara De Sandre-Giovannoli; Malika Chaouch; Serguei Kozlov; Jean-Michel Vallat; Meriem Tazir; Nadia Kassouri; Pierre Szepetowski; Tarik Hammadouche; Antoon Vandenberghe; Colin L Stewart; Djamel Grid; Nicolas Lévy
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Journal: Nature Date: 2002-01-03 Impact factor: 49.962

6. Smooth muscle cell depletion and collagen types in progeric arteries.

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Journal: Cardiovasc Pathol Date: 2001 May-Jun Impact factor: 2.185

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Authors: Alberto M Pendás; Zhongjun Zhou; Juan Cadiñanos; José M P Freije; Jianming Wang; Kjell Hultenby; Aurora Astudillo; Annika Wernerson; Francisco Rodríguez; Karl Tryggvason; Carlos López-Otín
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Authors: Arun K Roy; Thomas Oh; Omar Rivera; James Mubiru; Chung S Song; Bandana Chatterjee
Journal: Ageing Res Rev Date: 2002-06 Impact factor: 10.895

Review 10. Development of bisphosphonates.

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64 in total

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Review 3. The genetics of ageing.

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4. Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.

Authors: Hea-Jin Jung; Catherine Coffinier; Youngshik Choe; Anne P Beigneux; Brandon S J Davies; Shao H Yang; Richard H Barnes; Janet Hong; Tao Sun; Samuel J Pleasure; Stephen G Young; Loren G Fong
Journal: Proc Natl Acad Sci U S A Date: 2012-01-30 Impact factor: 11.205

Review 5. Inhibition of Ras for cancer treatment: the search continues.

Authors: Antonio T Baines; Dapeng Xu; Channing J Der
Journal: Future Med Chem Date: 2011-10 Impact factor: 3.808

Review 6. A humanized yeast system to analyze cleavage of prelamin A by ZMPSTE24.

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Journal: Methods Date: 2019-01-06 Impact factor: 3.608

Review 7. Age-related neurodegenerative diseases.

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Journal: J Cell Physiol Date: 2019-09-25 Impact factor: 6.384

8. Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration.

Authors: Hea-Jin Jung; Chika Nobumori; Chris N Goulbourne; Yiping Tu; John M Lee; Angelica Tatar; Daniel Wu; Yuko Yoshinaga; Pieter J de Jong; Catherine Coffinier; Loren G Fong; Stephen G Young
Journal: Proc Natl Acad Sci U S A Date: 2013-05-06 Impact factor: 11.205

9. Investigation of splicing changes and post-translational processing of LMNA in sporadic inclusion body myositis.

Authors: Yue-Bei Luo; Chalermchai Mitrpant; Russell Johnsen; Vicki Fabian; Merrilee Needham; Sue Fletcher; Steve D Wilton; Frank L Mastaglia
Journal: Int J Clin Exp Pathol Date: 2013-08-15

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Authors: Hea-Jin Jung; John M Lee; Shao H Yang; Stephen G Young; Loren G Fong
Journal: Mol Neurobiol Date: 2012-10-14 Impact factor: 5.590