Literature DB >> 22416132

Understanding the roles of nuclear A- and B-type lamins in brain development.

Stephen G Young1, Hea-Jin Jung, Catherine Coffinier, Loren G Fong.   

Abstract

The nuclear lamina is composed mainly of lamins A and C (A-type lamins) and lamins B1 and B2 (B-type lamins). Dogma has held that lamins B1 and B2 play unique and essential roles in the nucleus of every eukaryotic cell. Recent studies have raised doubts about that view but have uncovered crucial roles for lamins B1 and B2 in neuronal migration during the development of the brain. The relevance of lamins A and C in the brain remains unclear, but it is intriguing that prelamin A expression in the brain is low and is regulated by miR-9, a brain-specific microRNA.

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Year:  2012        PMID： 22416132      PMCID： PMC3351360          DOI： 10.1074/jbc.R112.354407

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  72 in total

1.  Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency.

Authors:  Catherine Coffinier; Sandy Y Chang; Chika Nobumori; Yiping Tu; Emily A Farber; Julia I Toth; Loren G Fong; Stephen G Young
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-09       Impact factor: 11.205

2.  Genomic duplications mediate overexpression of lamin B1 in adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms.

Authors:  Jens Schuster; Jimmy Sundblom; Ann-Charlotte Thuresson; Sharon Hassin-Baer; Thomas Klopstock; Martin Dichgans; Oren S Cohen; Raili Raininko; Atle Melberg; Niklas Dahl
Journal:  Neurogenetics       Date:  2011-01-12       Impact factor: 2.660

3.  Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice.

Authors:  Catherine Coffinier; Hea-Jin Jung; Ziwei Li; Chika Nobumori; Ui Jeong Yun; Emily A Farber; Brandon S Davies; Michael M Weinstein; Shao H Yang; Jan Lammerding; Javad N Farahani; Laurent A Bentolila; Loren G Fong; Stephen G Young
Journal:  J Biol Chem       Date:  2010-05-03       Impact factor: 5.157

4.  An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria.

Authors:  Brandon S J Davies; Richard H Barnes; Yiping Tu; Shuxun Ren; Douglas A Andres; H Peter Spielmann; Jan Lammerding; Yibin Wang; Stephen G Young; Loren G Fong
Journal:  Hum Mol Genet       Date:  2010-04-26       Impact factor: 6.150

5.  Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria.

Authors:  Lidia Hernandez; Kyle J Roux; Esther Sook Miin Wong; Leslie C Mounkes; Rafidah Mutalif; Raju Navasankari; Bina Rai; Simon Cool; Jae-Wook Jeong; Honghe Wang; Hyun-Shik Lee; Serguei Kozlov; Martin Grunert; Thomas Keeble; C Michael Jones; Margarita D Meta; Stephen G Young; Ira O Daar; Brian Burke; Alan O Perantoni; Colin L Stewart
Journal:  Dev Cell       Date:  2010-09-14       Impact factor: 12.270

6.  Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.

Authors:  Shao H Yang; Sandy Y Chang; Shuxun Ren; Yibin Wang; Douglas A Andres; H Peter Spielmann; Loren G Fong; Stephen G Young
Journal:  Hum Mol Genet       Date:  2010-11-18       Impact factor: 6.150

7.  The nuclear envelope can control gene expression and cell cycle progression via miRNA regulation.

Authors:  Ashraf Malhas; Nigel J Saunders; David J Vaux
Journal:  Cell Cycle       Date:  2010-02-01       Impact factor: 4.534

8.  The functions of Klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye.

Authors:  Kristin Patterson; Ari B Molofsky; Christina Robinson; Shelley Acosta; Courtney Cater; Janice A Fischer
Journal:  Mol Biol Cell       Date:  2003-11-14       Impact factor: 4.138

9.  Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.

Authors:  Roger Lee; Sandy Y Chang; Hung Trinh; Yiping Tu; Andrew C White; Brandon S J Davies; Martin O Bergo; Loren G Fong; William E Lowry; Stephen G Young
Journal:  Hum Mol Genet       Date:  2010-01-27       Impact factor: 6.150

10.  Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation.

Authors:  Stephanie K Mewborn; Megan J Puckelwartz; Fida Abuisneineh; John P Fahrenbach; Yuan Zhang; Heather MacLeod; Lisa Dellefave; Peter Pytel; Sara Selig; Christine M Labno; Karen Reddy; Harinder Singh; Elizabeth McNally
Journal:  PLoS One       Date:  2010-12-14       Impact factor: 3.240
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  32 in total

1.  Developmental regulation of linkers of the nucleoskeleton to the cytoskeleton during mouse postnatal retinogenesis.

Authors:  David S Razafsky; Candace L Ward; Thorsten Kolb; Didier Hodzic
Journal:  Nucleus       Date:  2013-08-23       Impact factor: 4.197

2.  Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration.

Authors:  Hea-Jin Jung; Chika Nobumori; Chris N Goulbourne; Yiping Tu; John M Lee; Angelica Tatar; Daniel Wu; Yuko Yoshinaga; Pieter J de Jong; Catherine Coffinier; Loren G Fong; Stephen G Young
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-06       Impact factor: 11.205

3.  Nuclear lamina builds tissues from the stem cell niche.

Authors:  Haiyang Chen; Yixian Zheng
Journal:  Fly (Austin)       Date:  2014       Impact factor: 2.160

4.  Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures.

Authors:  Natalie Y Chen; Paul Kim; Thomas A Weston; Lovelyn Edillo; Yiping Tu; Loren G Fong; Stephen G Young
Journal:  Proc Natl Acad Sci U S A       Date:  2018-09-17       Impact factor: 11.205

Review 5.  The nuclear lamins: flexibility in function.

Authors:  Brian Burke; Colin L Stewart
Journal:  Nat Rev Mol Cell Biol       Date:  2012-12-05       Impact factor: 94.444

Review 6.  Nuclear lamins and neurobiology.

Authors:  Stephen G Young; Hea-Jin Jung; John M Lee; Loren G Fong
Journal:  Mol Cell Biol       Date:  2014-05-19       Impact factor: 4.272

7.  Do lamin B1 and lamin B2 have redundant functions?

Authors:  John M Lee; Hea-Jin Jung; Loren G Fong; Stephen G Young
Journal:  Nucleus       Date:  2014 Jul-Aug       Impact factor: 4.197

8.  De Novo Variants in LMNB1 Cause Pronounced Syndromic Microcephaly and Disruption of Nuclear Envelope Integrity.

Authors:  Francesca Cristofoli; Tonya Moss; Hannah W Moore; Koen Devriendt; Heather Flanagan-Steet; Melanie May; Julie Jones; Filip Roelens; Carmen Fons; Anna Fernandez; Loreto Martorell; Angelo Selicorni; Silvia Maitz; Giuseppina Vitiello; Gerd Van der Hoeven; Steven A Skinner; Mathieu Bollen; Joris R Vermeesch; Richard Steet; Hilde Van Esch
Journal:  Am J Hum Genet       Date:  2020-09-09       Impact factor: 11.025

9.  An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death.

Authors:  Natalie Y Chen; Ye Yang; Thomas A Weston; Jason N Belling; Patrick Heizer; Yiping Tu; Paul Kim; Lovelyn Edillo; Steven J Jonas; Paul S Weiss; Loren G Fong; Stephen G Young
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-03       Impact factor: 11.205

10.  Lamins Organize the Global Three-Dimensional Genome from the Nuclear Periphery.

Authors:  Xiaobin Zheng; Jiabiao Hu; Sibiao Yue; Lidya Kristiani; Miri Kim; Michael Sauria; James Taylor; Youngjo Kim; Yixian Zheng
Journal:  Mol Cell       Date:  2018-06-28       Impact factor: 17.970
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