BACKGROUND/AIMS: Mucosa marking targeting biopsy (MTB) technique has been tested and verified in animal model. For multi-focal atrophic gastritis, random biopsy may miss the point of atrophy, intestinal metaplasia or dysplasia. In order to monitor chronic atrophic gastritis on gastroscopy, get the proper biopsy sample is very important. METHODOLOGY: Fifty-three atrophic gastritis patients were enrolled prospectively in this study. India ink was tattooed at five points of stomach. Endoscopy was repeated at 3, 9, 15 and 24 months. RESULTS: Tattoos (96.2%) produced with 1:10 concertrations were visible with a good to excellent tattoo persistence at 3 months. Only two patients (3.8%) had poor tattoo persistence and were retattooed at 3-months interval. Tattoos did not disappear in patients who repeated for more than two gastroscopies at 24 months or even long. There were no complications related to India ink tattooing including abdominal pain, bleeding or perforation. At follow-up gastroscopy, no ulcers, inflammation, break in the mucosa, or pain was noted. CONCLUSIONS: Clinical use of MTB technique is safe and persistence and may be used as an effective method for longitudinal follow-up in atrophic gastritis and other precancerous lesions.
BACKGROUND/AIMS: Mucosa marking targeting biopsy (MTB) technique has been tested and verified in animal model. For multi-focal atrophic gastritis, random biopsy may miss the point of atrophy, intestinal metaplasia or dysplasia. In order to monitor chronic atrophic gastritis on gastroscopy, get the proper biopsy sample is very important. METHODOLOGY: Fifty-three atrophic gastritispatients were enrolled prospectively in this study. India ink was tattooed at five points of stomach. Endoscopy was repeated at 3, 9, 15 and 24 months. RESULTS: Tattoos (96.2%) produced with 1:10 concertrations were visible with a good to excellent tattoo persistence at 3 months. Only two patients (3.8%) had poor tattoo persistence and were retattooed at 3-months interval. Tattoos did not disappear in patients who repeated for more than two gastroscopies at 24 months or even long. There were no complications related to India ink tattooing including abdominal pain, bleeding or perforation. At follow-up gastroscopy, no ulcers, inflammation, break in the mucosa, or pain was noted. CONCLUSIONS: Clinical use of MTB technique is safe and persistence and may be used as an effective method for longitudinal follow-up in atrophic gastritis and other precancerous lesions.
Authors: Minoru Fujita; Kevin M McGrath; Rita Bottino; Eefje M Dons; Cassandra Long; Goutham Kumar; Burcin Ekser; Gabriel J Echeverri; Jiro Hata; Ken Haruma; David K C Cooper; Hidetaka Hara Journal: Cell Transplant Date: 2013-01-16 Impact factor: 4.064
Authors: Ana Isabel Gonzalez-Tallon; Miguel Rivero-Fernandez; Irina Calvo-Ramos; Antonio Diaz-Sanchez; Maria Del Rosario Gonzalez-Alonso; Elsa De la Fuente-Briongos; Rebeba Manzano-Fernandez; Eloisa Moya-Valverde; Jose Maria Riesco-Lopez; Rocio Campos-Cantero Journal: Gastroenterology Res Date: 2017-02-21
Authors: Weiling Hu; Bin Wang; Leimin Sun; Shujie Chen; Liangjing Wang; Kan Wang; Jiaguo Wu; John J Kim; Jiquan Liu; Ning Dai; Huilong Duan; Jianmin Si Journal: Biomed Res Int Date: 2015-04-14 Impact factor: 3.411