Literature DB >> 19449443

p21(WAF1/CIP1) and cancer: a shifting paradigm?

Andrei L Gartel1.   

Abstract

The cyclin-dependent kinase inhibitor p21(WAF1/CIP1) is a key mediator of p53-dependent cell cycle arrest and may play the role of a tumor suppressor in cancer. However, it has been shown that p21 may also act as an oncogene, because it inhibits apoptosis and may promote cell proliferation in some tumors. These data point out to "antagonistic duality" of p21, because it possesses anticancer and procancer properties at the same time. New data suggest that more and more proteins also may play contradictory roles in cancer thus challenging current paradigm of established oncogenes and tumor suppressors. (c) 2009 International Union of Biochemistry and Molecular Biology, Inc.

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Year:  2009        PMID： 19449443     DOI： 10.1002/biof.26

Source DB:  PubMed          Journal:  Biofactors        ISSN： 0951-6433            Impact factor:   6.113


  34 in total

1.  NF-Y is necessary for hematopoietic stem cell proliferation and survival.

Authors:  Gerd Bungartz; Hannah Land; David T Scadden; Stephen G Emerson
Journal:  Blood       Date:  2011-11-09       Impact factor: 22.113

Review 2.  Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling.

Authors:  Søren T Christensen; Christian A Clement; Peter Satir; Lotte B Pedersen
Journal:  J Pathol       Date:  2011-11-21       Impact factor: 7.996

Review 3.  Multiple functions of p21 in cancer radiotherapy.

Authors:  Yanbei Kuang; Jian Kang; Hongbin Li; Bingtao Liu; Xueshan Zhao; Linying Li; Xiaodong Jin; Qiang Li
Journal:  J Cancer Res Clin Oncol       Date:  2021-02-05       Impact factor: 4.553

4.  Over-expression of p53, p21 and Cdc2 in histologically negative surgical margins is correlated with local recurrence of laryngeal squamous cell carcinoma.

Authors:  Jun-Quan Yang; Hong-Xia Liu; Zhen Liang; Yu-Man Sun; Meng Wu
Journal:  Int J Clin Exp Pathol       Date:  2014-06-15

5.  Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice.

Authors:  Marianna L Ianzano; Stefania Croci; Giordano Nicoletti; Arianna Palladini; Lorena Landuzzi; Valentina Grosso; Dario Ranieri; Massimiliano Dall'Ora; Ilaria Santeramo; Milena Urbini; Carla De Giovanni; Pier-Luigi Lollini; Patrizia Nanni
Journal:  Oncotarget       Date:  2014-01-15

6.  Nrf2 inhibition sensitizes cholangiocarcinoma cells to cytotoxic and antiproliferative activities of chemotherapeutic agents.

Authors:  Papavee Samatiwat; Auemduan Prawan; Laddawan Senggunprai; Upa Kukongviriyapan; Veerapol Kukongviriyapan
Journal:  Tumour Biol       Date:  2016-03-25

7.  Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21(CIP1/WAF1) in the liver.

Authors:  M Yeganeh; Y Gui; R Kandhi; D Bobbala; W-S Tobelaim; C Saucier; A Yoshimura; G Ferbeyre; S Ramanathan; S Ilangumaran
Journal:  Oncogene       Date:  2016-01-04       Impact factor: 9.867

8.  Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase.

Authors:  Sofia Theodoropoulou; Paraskevi E Kolovou; Yuki Morizane; Maki Kayama; Fotini Nicolaou; Joan W Miller; Evangelos Gragoudas; Bruce R Ksander; Demetrios G Vavvas
Journal:  FASEB J       Date:  2010-04-06       Impact factor: 5.191

9.  Interleukin Enhancer Binding Factor 2 Regulates Cell Viability and Apoptosis of Human Brain Vascular Smooth Muscle Cells.

Authors:  Liang Wei; Cheng Yang; Guangxue Wang; Keqin Li; Yanfei Zhang; Hongxin Guan; Zhiyang Sun; Chunlong Zhong
Journal:  J Mol Neurosci       Date:  2020-08-04       Impact factor: 3.444

10.  Epigenetic changes in p21 expression in renal cells after exposure to bromate.

Authors:  N E Scholpa; X Zhang; R T Kolli; B S Cummings
Journal:  Toxicol Sci       Date:  2014-07-11       Impact factor: 4.849
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