Literature DB >> 19447333

One-pot fermentation of pladienolide D by Streptomyces platensis expressing a heterologous cytochrome P450 gene.

Kazuhiro Machida1, Yasuhide Aritoku, Toshio Tsuchida.   

Abstract

Pladienolide D is a 16-hydroxylated derivative of pladienolide B, produced by Streptomyces platensis. To facilitate the production of pladienolide D, the gene encoding a pladienolide B 16-hydroxylase from S. bungoensis was introduced into S. platensis. The recombinant produced pladienolide D at a production level comparable to that of pladienolide B.

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Year:  2009        PMID: 19447333     DOI: 10.1016/j.jbiosc.2009.01.023

Source DB:  PubMed          Journal:  J Biosci Bioeng        ISSN: 1347-4421            Impact factor:   2.894


  5 in total

Review 1.  Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.

Authors:  Jeffrey D Rudolf; Chin-Yuan Chang; Ming Ma; Ben Shen
Journal:  Nat Prod Rep       Date:  2017-08-30       Impact factor: 13.423

Review 2.  Diversity of P450 enzymes in the biosynthesis of natural products.

Authors:  Larissa M Podust; David H Sherman
Journal:  Nat Prod Rep       Date:  2012-07-23       Impact factor: 13.423

3.  Stabilized cyclopropane analogs of the splicing inhibitor FD-895.

Authors:  Reymundo Villa; Manoj Kumar Kashyap; Deepak Kumar; Thomas J Kipps; Januario E Castro; James J La Clair; Michael D Burkart
Journal:  J Med Chem       Date:  2013-08-21       Impact factor: 7.446

Review 4.  CYP105-diverse structures, functions and roles in an intriguing family of enzymes in Streptomyces.

Authors:  Suzy C Moody; E Joel Loveridge
Journal:  J Appl Microbiol       Date:  2014-11-04       Impact factor: 3.772

Review 5.  Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment.

Authors:  Nancy Martínez-Montiel; Nora Hilda Rosas-Murrieta; Mónica Martínez-Montiel; Mayra Patricia Gaspariano-Cholula; Rebeca D Martínez-Contreras
Journal:  Biomed Res Int       Date:  2016-08-16       Impact factor: 3.411

  5 in total

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