Literature DB >> 19447150

Animals models of MCH function and what they can tell us about its role in energy balance.

Pavlos Pissios1.   

Abstract

Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy expenditure in rodent models, and the central sites where MCH acts in regulating energy homeostasis. Emphasis is given on the discrepancies between the genetic and pharmacologic models of MCHR1 inactivation. We propose some solutions to resolve these discrepancies and discuss some future directions in MCH research.

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Year:  2009        PMID： 19447150      PMCID： PMC2977959          DOI： 10.1016/j.peptides.2009.05.002

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  62 in total

1.  Melanin-concentrating hormone (MCH) suppresses thyroid stimulating hormone (TSH) release, in vivo and in vitro, via the hypothalamus and the pituitary.

Authors:  A R Kennedy; J F Todd; S A Stanley; C R Abbott; C J Small; M A Ghatei; S R Bloom
Journal:  Endocrinology       Date:  2001-07       Impact factor: 4.736

2.  Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance.

Authors:  D S Ludwig; N A Tritos; J W Mastaitis; R Kulkarni; E Kokkotou; J Elmquist; B Lowell; J S Flier; E Maratos-Flier
Journal:  J Clin Invest       Date:  2001-02       Impact factor: 14.808

3.  Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression.

Authors:  Carina P Tan; Hideki Sano; Hisashi Iwaasa; Jie Pan; Andreas W Sailer; Donna L Hreniuk; Scott D Feighner; Oksana C Palyha; Sheng-Shung Pong; David J Figueroa; Christopher P Austin; Michael M Jiang; Hong Yu; Junko Ito; Makoto Ito; Masahiko Ito; Xiao Ming Guan; Douglas J MacNeil; Akio Kanatani; Lex H T Van der Ploeg; Andrew D Howard
Journal:  Genomics       Date:  2002-06       Impact factor: 5.736

4.  Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism.

Authors:  Donald J Marsh; Drew T Weingarth; Dawn E Novi; Howard Y Chen; Myrna E Trumbauer; Airu S Chen; Xiao-Ming Guan; Michael M Jiang; Yue Feng; Ramon E Camacho; Zhu Shen; Easter G Frazier; Hong Yu; Joseph M Metzger; Stephanie J Kuca; Lauren P Shearman; Shobhna Gopal-Truter; Douglas J MacNeil; Alison M Strack; D Euan MacIntyre; Lex H T Van der Ploeg; Su Qian
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-26       Impact factor: 11.205

5.  T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist.

Authors:  Shiro Takekawa; Asano Asami; Yuji Ishihara; Jun Terauchi; Kaneyoshi Kato; Yukio Shimomura; Masaaki Mori; Hitomi Murakoshi; Koki Kato; Nobuhiro Suzuki; Osamu Nishimura; Masahiko Fujino
Journal:  Eur J Pharmacol       Date:  2002-03-08       Impact factor: 4.432

6.  The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat.

Authors:  G J Hervieu; J E Cluderay; D Harrison; J Meakin; P Maycox; S Nasir; R A Leslie
Journal:  Eur J Neurosci       Date:  2000-04       Impact factor: 3.386

7.  Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity.

Authors:  Yanyun Chen; Changzhi Hu; Chiun-Kang Hsu; Qing Zhang; Chen Bi; Mark Asnicar; Hansen M Hsiung; Niles Fox; Lawrence J Slieker; Derek D Yang; Mark L Heiman; Yuguang Shi
Journal:  Endocrinology       Date:  2002-07       Impact factor: 4.736

8.  Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats.

Authors:  O Della-Zuana; F Presse; C Ortola; J Duhault; J L Nahon; N Levens
Journal:  Int J Obes Relat Metab Disord       Date:  2002-10

Review 9.  Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists.

Authors:  David R Luthin
Journal:  Life Sci       Date:  2007-06-27       Impact factor: 5.037

10.  Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist.

Authors:  Beth Borowsky; Margaret M Durkin; Kristine Ogozalek; Mohammad R Marzabadi; John DeLeon; Bharat Lagu; Rainer Heurich; Harvey Lichtblau; Zoya Shaposhnik; Irena Daniewska; Thomas P Blackburn; Theresa A Branchek; Christophe Gerald; Pierre J Vaysse; Carlos Forray
Journal:  Nat Med       Date:  2002-07-15       Impact factor: 53.440
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  17 in total

Review 1.  Molecular basis of the obesity associated with Bardet-Biedl syndrome.

Authors:  Deng-Fu Guo; Kamal Rahmouni
Journal:  Trends Endocrinol Metab       Date:  2011-04-21       Impact factor: 12.015

2.  Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling.

Authors:  Carmit Goldstein; Jonathan C Schroeder; Jean-Philippe Fortin; Jennifer M Goss; Scott E Schaus; Martin Beinborn; Alan S Kopin
Journal:  J Pharmacol Exp Ther       Date:  2010-09-10       Impact factor: 4.030

Review 3.  Obesity: Current and potential pharmacotherapeutics and targets.

Authors:  Vidya Narayanaswami; Linda P Dwoskin
Journal:  Pharmacol Ther       Date:  2016-10-20       Impact factor: 12.310

Review 4.  The melanin-concentrating hormone receptors: neuronal and non-neuronal functions.

Authors:  F Presse; G Conductier; C Rovere; J-L Nahon
Journal:  Int J Obes Suppl       Date:  2014-07-08

5.  Age-related loss of orexin/hypocretin neurons.

Authors:  B A Kessler; E M Stanley; D Frederick-Duus; J Fadel
Journal:  Neuroscience       Date:  2011-01-22       Impact factor: 3.590

6.  Inflammation-induced functional connectivity of melanin-concentrating hormone and IL-10.

Authors:  Dimitrios C Ziogas; Apostolos K A Karagiannis; Brenda M Geiger; Beatriz Gras-Miralles; Robert Najarian; Ofer Reizes; Leo R Fitzpatrick; Efi Kokkotou
Journal:  Peptides       Date:  2014-02-18       Impact factor: 3.750

Review 7.  Animal models in obesity and hypertension.

Authors:  Gabriella Segal-Lieberman; Talma Rosenthal
Journal:  Curr Hypertens Rep       Date:  2013-06       Impact factor: 5.369

8.  The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone.

Authors:  Melissa B Glier; Pavlos Pissios; Sandra L Babich; Marcia L E Macdonald; Michael R Hayden; Eleftheria Maratos-Flier; William T Gibson
Journal:  Peptides       Date:  2009-10-31       Impact factor: 3.750

Review 9.  Leptin receptor modulation of adiposity and fertility.

Authors:  Davelene Israel; Streamson Chua
Journal:  Trends Endocrinol Metab       Date:  2009-10-23       Impact factor: 12.015

10.  Acute escitalopram treatment inhibits REM sleep rebound and activation of MCH-expressing neurons in the lateral hypothalamus after long term selective REM sleep deprivation.

Authors:  Zita Kátai; Csaba Adori; Tamás Kitka; Szilvia Vas; Lajos Kalmár; Diána Kostyalik; László Tóthfalusi; Miklós Palkovits; György Bagdy
Journal:  Psychopharmacology (Berl)       Date:  2013-03-21       Impact factor: 4.530
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