Literature DB >> 19854659

Leptin receptor modulation of adiposity and fertility.

Davelene Israel1, Streamson Chua.   

Abstract

The leptin receptor was discovered as a leptin binding protein, which is highly expressed in the choroid plexus. Mapping of the gene's chromosomal locations in rodents revealed that mutations in Lepr were the basis of obesity/diabetes mutations in rodents and humans. Genetic manipulations that target Lepr expression in specific neurons or hypothalamic areas have generated insights into the modes by which body composition and reproductive function are modulated by the leptin receptor. These animal models have also been instrumental in identifying diabetes susceptibility genes. In this review we discuss the evidence that supports the concept of networked functions of leptin receptor as it pertains to feeding, substrate utilization and reproduction.

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Year:  2009        PMID： 19854659      PMCID： PMC2818174          DOI： 10.1016/j.tem.2009.07.004

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  65 in total

Review 1.  Mechanisms of leptin action and leptin resistance.

Authors:  Martin G Myers; Michael A Cowley; Heike Münzberg
Journal:  Annu Rev Physiol       Date:  2008       Impact factor: 19.318

2.  Neuronal PTP1B regulates body weight, adiposity and leptin action.

Authors:  Kendra K Bence; Mirela Delibegovic; Bingzhong Xue; Cem Z Gorgun; Gokhan S Hotamisligil; Benjamin G Neel; Barbara B Kahn
Journal:  Nat Med       Date:  2006-07-16       Impact factor: 53.440

3.  Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Authors:  Jennifer W Hill; Kevin W Williams; Chianping Ye; Ji Luo; Nina Balthasar; Roberto Coppari; Michael A Cowley; Lewis C Cantley; Bradford B Lowell; Joel K Elmquist
Journal:  J Clin Invest       Date:  2008-05       Impact factor: 14.808

4.  Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.

Authors:  Esther van de Wall; Rebecca Leshan; Allison W Xu; Nina Balthasar; Roberto Coppari; Shun Mei Liu; Young Hwan Jo; Robert G MacKenzie; David B Allison; Nae J Dun; Joel Elmquist; Bradford B Lowell; Gregory S Barsh; Carl de Luca; Martin G Myers; Gary J Schwartz; Streamson C Chua
Journal:  Endocrinology       Date:  2007-12-27       Impact factor: 4.736

5.  The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone.

Authors:  Heather M Dungan; Michelle L Gottsch; Hongkui Zeng; Alexander Gragerov; John E Bergmann; Demetrios K Vassilatis; Donald K Clifton; Robert A Steiner
Journal:  J Neurosci       Date:  2007-10-31       Impact factor: 6.167

6.  Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

Authors:  A Christine Könner; Ruth Janoschek; Leona Plum; Sabine D Jordan; Eva Rother; Xiaosong Ma; Chun Xu; Pablo Enriori; Brigitte Hampel; Gregory S Barsh; C Ronald Kahn; Michael A Cowley; Frances M Ashcroft; Jens C Brüning
Journal:  Cell Metab       Date:  2007-06       Impact factor: 27.287

7.  Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function.

Authors:  Marie Björnholm; Heike Münzberg; Rebecca L Leshan; Eneida C Villanueva; Sarah H Bates; Gwendolyn W Louis; Justin C Jones; Ryoko Ishida-Takahashi; Christian Bjørbaek; Martin G Myers
Journal:  J Clin Invest       Date:  2007-04-05       Impact factor: 14.808

8.  Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor.

Authors:  I Sadaf Farooqi; Teresia Wangensteen; Stephan Collins; Wendy Kimber; Giuseppe Matarese; Julia M Keogh; Emma Lank; Bill Bottomley; Judith Lopez-Fernandez; Ivan Ferraz-Amaro; Mehul T Dattani; Oya Ercan; Anne Grethe Myhre; Lars Retterstol; Richard Stanhope; Julie A Edge; Sheila McKenzie; Nader Lessan; Maryam Ghodsi; Veronica De Rosa; Francesco Perna; Silvia Fontana; Inês Barroso; Dag E Undlien; Stephen O'Rahilly
Journal:  N Engl J Med       Date:  2007-01-18       Impact factor: 91.245

9.  Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice.

Authors:  Marija Dokmanovic-Chouinard; Wendy K Chung; Jean-Claude Chevre; Elizabeth Watson; Jason Yonan; Beebe Wiegand; Yana Bromberg; Nao Wakae; Chris V Wright; John Overton; Sujoy Ghosh; Ganesh M Sathe; Carina E Ammala; Kathleen K Brown; Rokuro Ito; Charles LeDuc; Keely Solomon; Stuart G Fischer; Rudolph L Leibel
Journal:  PLoS Genet       Date:  2008-07-25       Impact factor: 5.917

Review 10.  Leptin receptor signaling and the regulation of mammalian physiology.

Authors:  E C Villanueva; M G Myers
Journal:  Int J Obes (Lond)       Date:  2008-12       Impact factor: 5.095
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  22 in total

1.  Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction.

Authors:  Davelene D Israel; Sharone Sheffer-Babila; Carl de Luca; Young-Hwan Jo; Shun Mei Liu; Qiu Xia; Daniel J Spergel; Siok L Dun; Nae J Dun; Streamson C Chua
Journal:  Endocrinology       Date:  2012-03-09       Impact factor: 4.736

2.  SH2B1--the adaptor protein that could.

Authors:  Streamson Chua
Journal:  Endocrinology       Date:  2010-09       Impact factor: 4.736

3.  Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection.

Authors:  Fnu Nagajyothi; Dazhi Zhao; Fabiana S Machado; Louis M Weiss; Gary J Schwartz; Mahalia S Desruisseaux; Yang Zhao; Stephen M Factor; Huan Huang; Chris Albanese; Mauro M Teixeira; Philipp E Scherer; Streamson C Chua; Herbert B Tanowitz
Journal:  J Infect Dis       Date:  2010-10-01       Impact factor: 5.226

4.  Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone.

Authors:  Cecilia Martin; Víctor M Navarro; Serap Simavli; Linh Vong; Rona S Carroll; Bradford B Lowell; Ursula B Kaiser
Journal:  J Neurosci       Date:  2014-04-23       Impact factor: 6.167

5.  ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice.

Authors:  Hu Huang; Seung Hwan Lee; Chianping Ye; Ines S Lima; Byung-Chul Oh; Bradford B Lowell; Janice M Zabolotny; Young-Bum Kim
Journal:  Endocrinology       Date:  2013-07-24       Impact factor: 4.736

6.  The role of leptin receptor gene polymorphisms in determining the susceptibility and prognosis of NSCLC in Chinese patients.

Authors:  Yuliang Li; Jianli Geng; Yongzheng Wang; Qinghua Lu; Yimeng Du; Wujie Wang; Zheng Li
Journal:  J Cancer Res Clin Oncol       Date:  2011-11-30       Impact factor: 4.553

7.  Sex hormones and adipokines in healthy pre-menopausal, post-menopausal and elderly women, and in age-matched men: data from the Brisighella Heart study.

Authors:  A F G Cicero; P Magni; P Lentini; M Ruscica; E Dozio; F Strollo; C Borghi
Journal:  J Endocrinol Invest       Date:  2010-12-15       Impact factor: 4.256

8.  Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility.

Authors:  Qi Wu; Benjamin B Whiddon; Richard D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-09       Impact factor: 11.205

9.  Comparison of Serum Leptin Level in Women with Unexplained Infertility and Fertile Women in Iran.

Authors:  Farzaneh Tafvizi; Masomeh Masomi
Journal:  J Obstet Gynaecol India       Date:  2016-02-26

10.  Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproduction.

Authors:  Sharone Sheffer-Babila; Yan Sun; Davelene D Israel; Shun-Mei Liu; Genevieve Neal-Perry; Streamson C Chua
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-10-29       Impact factor: 4.310
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