Literature DB >> 19447146

Context dependent effects of ventral tegmental area inactivation on spatial working memory.

Adria K Martig1, Graham L Jones, Kelsey E Smith, Sheri J Y Mizumori.   

Abstract

Rats were tested on a hippocampus dependent win-shift working memory task in familiar or novel environments after receiving bilateral ventral tegmental area infusions of baclofen. Baclofen infusion disrupted working memory performance in both familiar and novel environments. In addition, baclofen infusion selectively disrupted short-term working memory in the novel environment. This experiment confirms selective ventral tegmental area support of accurate performance during a context dependent spatial navigation task.

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Year:  2009        PMID: 19447146      PMCID: PMC2709700          DOI: 10.1016/j.bbr.2009.05.008

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN: 0166-4328            Impact factor:   3.332


  34 in total

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  8 in total

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