Literature DB >> 19447085

Rethinking how hearing happens.

Zhigang Xu1, Anthony J Ricci, Stefan Heller.   

Abstract

Inner ear hair cells convert hair bundle deflection into mechanical force sensed by ion channels via extracellular tip links between adjacent stereocilia. In this Neuron issue, Grillet and colleagues show the protein harmonin mechanically reinforces tip link upper insertion sites. Harmonin loss at this site reduces mechanotransduction kinetics and sensitivity.

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Year:  2009        PMID： 19447085      PMCID： PMC3246801          DOI： 10.1016/j.neuron.2009.04.019

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  15 in total

Review 1.  The micromachinery of mechanotransduction in hair cells.

Authors:  Melissa A Vollrath; Kelvin Y Kwan; David P Corey
Journal:  Annu Rev Neurosci       Date:  2007       Impact factor: 12.449

2.  Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations.

Authors:  C J Kros; W Marcotti; S M van Netten; T J Self; R T Libby; S D M Brown; G P Richardson; K P Steel
Journal:  Nat Neurosci       Date:  2002-01       Impact factor: 24.884

3.  Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle.

Authors:  Batiste Boëda; Aziz El-Amraoui; Amel Bahloul; Richard Goodyear; Laurent Daviet; Stéphane Blanchard; Isabelle Perfettini; Karl R Fath; Spencer Shorte; Jan Reiners; Anne Houdusse; Pierre Legrain; Uwe Wolfrum; Guy Richardson; Christine Petit
Journal:  EMBO J       Date:  2002-12-16       Impact factor: 11.598

4.  Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction.

Authors:  J O Pickles; S D Comis; M P Osborne
Journal:  Hear Res       Date:  1984-08       Impact factor: 3.208

5.  Cross-links between stereocilia in the guinea pig cochlea.

Authors:  D N Furness; C M Hackney
Journal:  Hear Res       Date:  1985-05       Impact factor: 3.208

6.  A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

Authors:  Jeffrey R Holt; Susan K H Gillespie; D William Provance; Kavita Shah; Kevan M Shokat; David P Corey; John A Mercer; Peter G Gillespie
Journal:  Cell       Date:  2002-02-08       Impact factor: 41.582

7.  Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.

Authors:  Piotr Kazmierczak; Hirofumi Sakaguchi; Joshua Tokita; Elizabeth M Wilson-Kubalek; Ronald A Milligan; Ulrich Müller; Bechara Kachar
Journal:  Nature       Date:  2007-09-06       Impact factor: 49.962

8.  Cadherin 23 is a component of the tip link in hair-cell stereocilia.

Authors:  Jan Siemens; Concepcion Lillo; Rachel A Dumont; Anna Reynolds; David S Williams; Peter G Gillespie; Ulrich Müller
Journal:  Nature       Date:  2004-03-31       Impact factor: 49.962

9.  A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.

Authors:  Gaelle Lefèvre; Vincent Michel; Dominique Weil; Léa Lepelletier; Emilie Bizard; Uwe Wolfrum; Jean-Pierre Hardelin; Christine Petit
Journal:  Development       Date:  2008-03-13       Impact factor: 6.868

10.  Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene.

Authors:  Kenneth R Johnson; Leona H Gagnon; Lisa S Webb; Luanne L Peters; Norman L Hawes; Bo Chang; Qing Yin Zheng
Journal:  Hum Mol Genet       Date:  2003-09-30       Impact factor: 6.150
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  2 in total

1.  Compound heterozygosity of the functionally null Cdh23(v-ngt) and hypomorphic Cdh23(ahl) alleles leads to early-onset progressive hearing loss in mice.

Authors:  Yuki Miyasaka; Sari Suzuki; Yasuhiro Ohshiba; Kei Watanabe; Yoshihiko Sagara; Shumpei P Yasuda; Kunie Matsuoka; Hiroshi Shitara; Hiromichi Yonekawa; Ryo Kominami; Yoshiaki Kikkawa
Journal:  Exp Anim       Date:  2013

Review 2.  Usher Syndrome: Genetics and Molecular Links of Hearing Loss and Directions for Therapy.

Authors:  Meg Whatley; Abbie Francis; Zi Ying Ng; Xin Ee Khoh; Marcus D Atlas; Rodney J Dilley; Elaine Y M Wong
Journal:  Front Genet       Date:  2020-10-22       Impact factor: 4.599
  2 in total

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