| Literature DB >> 19435664 |
Rita Capela1, Rudi Oliveira, Lídia M Gonçalves, Ana Domingos, Jiri Gut, Philip J Rosenthal, Francisca Lopes, Rui Moreira.
Abstract
A series of artemisinin-vinyl sulfone hybrid molecules with the potential to act in the parasite food vacuole via endoperoxide activation and falcipain inhibition was synthesized and screened for antiplasmodial activity and falcipain-2 inhibition. All conjugates were active against the Plasmodium falciparum W2 strain in the low nanomolar range and those containing the Leu-hPhe core inhibited falcipain-2 in low micromolar range.Entities:
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Year: 2009 PMID： 19435664 PMCID： PMC2742655 DOI： 10.1016/j.bmcl.2009.04.100
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823