| Literature DB >> 19434561 |
A Heinz1, A Beck, J Wrase, J Mohr, K Obermayer, J Gallinat, I Puls.
Abstract
An interplay of different neurotransmitter systems has been implicated in the development and maintenance of alcohol dependence. Here we focus on neuroadaptations in reward-related neurotransmitter systems and their impact on central processing of alcohol-associated and reward-indicating stimuli. We discuss genotype effects on cue-induced neuronal activation and present new computational methods based on machine learning to deal with complex genotype-phenotype interactions, e.g. between brain atrophy and genes associated with glutamatergic and dopaminergic neurotransmission.Entities:
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Year: 2009 PMID: 19434561 DOI: 10.1055/s-0029-1214395
Source DB: PubMed Journal: Pharmacopsychiatry ISSN: 0176-3679 Impact factor: 5.788