BACKGROUND: We present outcome data from concurrent chemotherapy and intensity-modulated radiation therapy (IMRT) for squamous cell carcinoma (SCC) of the larynx and oropharyx. METHODS: Eighty patients with laryngeal (n = 15) or oropharyngeal (n = 65) SCC underwent concurrent IMRT and chemotherapy (cisplatin or carboplatin/paclitaxel). RESULTS: The 3-year overall survival (OS) and disease-free survival (DFS) were 81.2% and 78.3%, respectively, with a median follow-up of 31.2 months. There was a statistically significant correlation between OS and DFS with N classification (p = .0001), but not with disease site or T classification. Toxicities compared favorably with prior reports using conventional radiation therapy. CONCLUSIONS: This retrospective analysis reveals a very good outcome and an acceptable toxicity profile for patients with locally advanced SCC of the oropharynx and larynx treated with chemotherapy and IMRT concurrently. (c) 2009 Wiley Periodicals, Inc. Head Neck, 2009.
BACKGROUND: We present outcome data from concurrent chemotherapy and intensity-modulated radiation therapy (IMRT) for squamous cell carcinoma (SCC) of the larynx and oropharyx. METHODS: Eighty patients with laryngeal (n = 15) or oropharyngeal (n = 65) SCC underwent concurrent IMRT and chemotherapy (cisplatin or carboplatin/paclitaxel). RESULTS: The 3-year overall survival (OS) and disease-free survival (DFS) were 81.2% and 78.3%, respectively, with a median follow-up of 31.2 months. There was a statistically significant correlation between OS and DFS with N classification (p = .0001), but not with disease site or T classification. Toxicities compared favorably with prior reports using conventional radiation therapy. CONCLUSIONS: This retrospective analysis reveals a very good outcome and an acceptable toxicity profile for patients with locally advanced SCC of the oropharynx and larynx treated with chemotherapy and IMRT concurrently. (c) 2009 Wiley Periodicals, Inc. Head Neck, 2009.
Authors: Martin Canis; Friedrich Ihler; Hendrik A Wolff; Hans Christiansen; Christoph Matthias; Wolfgang Steiner Journal: Eur Arch Otorhinolaryngol Date: 2012-07-05 Impact factor: 2.503
Authors: Gregory Vlacich; Roberto Diaz; Steven W Thorpe; Barbara A Murphy; Wyndee Kirby; Robert J Sinard; Bashar Shakhtour; Yu Shyr; Patrick Murphy; James L Netterville; Wendell G Yarbrough; Anthony J Cmelak Journal: Oncologist Date: 2012-05-01
Authors: Paul Kerr; Candace L Myers; James Butler; Mohamed Alessa; Pascal Lambert; Andrew L Cooke Journal: J Otolaryngol Head Neck Surg Date: 2015-05-13