| Literature DB >> 19429674 |
Jan Christiansen1, Astrid M Kolte, Thomas v O Hansen, Finn C Nielsen.
Abstract
Recent genome-wide association (GWA) studies of type 2 diabetes (T2D) have implicated IGF2 mRNA-binding protein 2 (IMP2/IGF2BP2) as one of the several factors in the etiology of late onset diabetes. IMP2 belongs to a family of oncofetal mRNA-binding proteins implicated in RNA localization, stability, and translation that are essential for normal embryonic growth and development. This review provides a background to the IMP protein family with an emphasis on human IMP2, followed by a closer look at the GWA studies to evaluate the significance, if any, of the proposed correlation between IMP2 and T2D.Entities:
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Year: 2009 PMID： 19429674 DOI： 10.1677/JME-09-0016
Source DB: PubMed Journal: J Mol Endocrinol ISSN： 0952-5041 Impact factor: 5.098