| Literature DB >> 19429407 |
Suzanne E Fenton1, Jessica L Reiner2, Shoji F Nakayama2, Amy D Delinsky3, Jason P Stanko4, Erin P Hines4, Sally S White5, Andrew B Lindstrom3, Mark J Strynar3, Syrago-Styliani E Petropoulou2.
Abstract
Previous studies in mice with multiple gestational exposures to perfluorooctanoic acid (PFOA) demonstrate numerous dose dependent growth and developmental effects which appeared to worsen if offspring exposed in utero nursed from PFOA-exposed dams. To evaluate the disposition of PFOA in the pregnant and lactating dam and her offspring, time-pregnant CD-1 mice received a single 0, 0.1, 1, or 5mg PFOA/kg BW dose (n=25/dose group) by gavage on gestation day 17. Maternal and pup fluids and tissues were collected over time. Pups exhibited significantly higher serum PFOA concentrations than their respective dams, and their body burden increased after birth until at least postnatal day 8, regardless of dose. The distribution of milk:serum PFOA varied by dose and time, but was typically in excess of 0.20. These data suggest that milk is a substantial PFOA exposure route in mice and should be considered in risk assessment modeling designs for this compound.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19429407 PMCID： PMC3446208 DOI： 10.1016/j.reprotox.2009.02.012
Source DB: PubMed Journal: Reprod Toxicol ISSN： 0890-6238 Impact factor: 3.143