| Literature DB >> 19429005 |
Christian Wider1, Sarah J Lincoln, Michael G Heckman, Nancy N Diehl, Jeremy T Stone, Kristoffer Haugarvoll, Jan O Aasly, J Mark Gibson, Timothy Lynch, Alex Rajput, Michele L Rajput, Ryan J Uitti, Zbigniew K Wszolek, Matthew J Farrer, Owen A Ross.
Abstract
Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P=0.032), Canadian (OR: 1.41, P=0.014) and Irish (OR: 1.44, P=0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P=0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P<0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.Entities:
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Year: 2009 PMID： 19429005 PMCID： PMC2684848 DOI： 10.1016/j.neulet.2009.02.009
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046