Comparison of clinically relevant findings from high-speed fourier-domain and conventional time-domain optical coherence tomography.

PURPOSE: To compare the sensitivities of high-speed Fourier-domain optical coherence tomography (FD-OCT) and conventional time-domain (TD) OCT for the detection of clinical findings important in the management of common vitreoretinal disorders.
DESIGN: Prospective, observational study.
METHODS: FD-OCT scans (128 B scans x 512 A scans) were obtained using a prototype instrument (3 D-OCT; Topcon, Tokyo, Japan) in 50 eyes of 28 consecutive patients undergoing conventional high-resolution (6 B scans x 512 A scans) TD-OCT imaging (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA). Each image set was reviewed independently for the presence of clinical findings of interest, and device sensitivities were calculated.
RESULTS: The average sensitivity for detection of all features in this study was 94% for FD-OCT and 60% for TD-OCT. Clinical findings were identical between devices in 18% (9/50) of cases. FD-OCT detected features that were not visible on conventional OCT scans in 78% (39/50) of cases. FD-OCT was more sensitive than TD-OCT for the detection of multiple findings, including diffuse intraretinal edema (87% vs 60.9%), subretinal fluid (100% vs 46.2%), large pigment epithelium detachments (100% vs 81%), and subretinal tissue (100% vs 61.5%).
CONCLUSIONS: FD-OCT seems to be superior to TD-OCT for the detection of many clinically relevant features of vitreoretinal disease. The greater sensitivity of FD-OCT systems for the detection of intraretinal and subretinal fluid may be of particular importance for the treatment of patients with neovascular age-related macular edema. FD-OCT is likely to supplant TD-OCT as the standard of care for retinal specialists in the near future.