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Literature DB >> 19427247

Regeneration: The origin of cancer or a possible cure?

Abstract

A better understanding of the forces controlling cell growth will be essential for developing effective therapies in regenerative medicine and cancer. Historically, the literature has linked cancer and tissue regeneration-proposing regeneration as both the source of cancer and a method to inhibit tumorigenesis. This review discusses two powerful regeneration models, the vertebrate urodele amphibians and invertebrate planarians, in light of cancer regulation. Urodele limb and eye lens regeneration is described, as well as the planarian's emergence as a molecular and genetic model system in which recent insights begin to molecularly dissect cancer and regeneration in adult tissues.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2009 PMID： 19427247 PMCID： PMC2706275 DOI： 10.1016/j.semcdb.2009.04.005

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

62 in total

Review 1. Inducing cellular dedifferentiation: a potential method for enhancing endogenous regeneration in mammals.

Authors: Shannon J Odelberg
Journal: Semin Cell Dev Biol Date: 2002-10 Impact factor: 7.727

Review 2. Signaling during lens regeneration.

Authors: Matthew W Grogg; Mindy K Call; Panagiotis A Tsonis
Journal: Semin Cell Dev Biol Date: 2006-10-27 Impact factor: 7.727

Review 3. Vertebrate limb regeneration and the origin of limb stem cells.

Authors: Susan V Bryant; Tetsuya Endo; David M Gardiner
Journal: Int J Dev Biol Date: 2002 Impact factor: 2.203

4. Induction of ocular tumor by nickel subsulfide in the Japanese common newt, Cynops pyrrhogaster.

Authors: M Okamoto
Journal: Cancer Res Date: 1987-10-01 Impact factor: 12.701

5. Neoplastic transformation in the planarian: II. Ultrastructure of malignant reticuloma.

Authors: F Hall; M Morita; J B Best
Journal: J Exp Zool Date: 1986-11

Review 6. Toll-like receptors, wound healing, and carcinogenesis.

Authors: Johannes Kluwe; Ali Mencin; Robert F Schwabe
Journal: J Mol Med (Berl) Date: 2008-12-17 Impact factor: 4.599

7. Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish.

Authors: R Samuel Rajendran; Marianne M Zupanc; Andreas Lösche; Jurjen Westra; Jerold Chun; Günther K H Zupanc
Journal: Dev Neurobiol Date: 2007-09-01 Impact factor: 3.964

8. Formaldehyde-based whole-mount in situ hybridization method for planarians.

Authors: Bret J Pearson; George T Eisenhoffer; Kyle A Gurley; Jochen C Rink; Diane E Miller; Alejandro Sánchez Alvarado
Journal: Dev Dyn Date: 2009-02 Impact factor: 3.780

Review 9. Limb regeneration revisited.

Authors: Jessica L Whited; Clifford J Tabin
Journal: J Biol Date: 2009-01-13

10. Genetic architecture of mouse skin inflammation and tumour susceptibility.

Authors: David A Quigley; Minh D To; Jesús Pérez-Losada; Facundo G Pelorosso; Jian-Hua Mao; Hiroki Nagase; David G Ginzinger; Allan Balmain
Journal: Nature Date: 2009-01-11 Impact factor: 49.962

40 in total

1. A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration.

Authors: Wendy S Beane; Junji Morokuma; Dany S Adams; Michael Levin
Journal: Chem Biol Date: 2011-01-28

Regeneration: The origin of cancer or a possible cure?

Review 1. Inducing cellular dedifferentiation: a potential method for enhancing endogenous regeneration in mammals.

Review 2. Signaling during lens regeneration.

Review 3. Vertebrate limb regeneration and the origin of limb stem cells.

4. Induction of ocular tumor by nickel subsulfide in the Japanese common newt, Cynops pyrrhogaster.

5. Neoplastic transformation in the planarian: II. Ultrastructure of malignant reticuloma.

Review 6. Toll-like receptors, wound healing, and carcinogenesis.

7. Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish.

8. Formaldehyde-based whole-mount in situ hybridization method for planarians.

Review 9. Limb regeneration revisited.

10. Genetic architecture of mouse skin inflammation and tumour susceptibility.

1. A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration.

2. Reference genes for qPCR assays in toxic metal and salinity stress in two flatworm model organisms.

3. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program.

4. The use of lectins as markers for differentiated secretory cells in planarians.

Review 5. Epithelial cancers in the post-genomic era: should we reconsider our lifestyle?

6. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

Review 7. Insights into regeneration tool box: An animal model approach.

Review 8. DNA damage and tissue repair: What we can learn from planaria.

9. The homeobox transcription factor Barx2 regulates plasticity of young primary myofibers.

10. Tumor suppressors: enhancers or suppressors of regeneration?