Literature DB >> 19425616

Novel one-pot, three-component synthesis of spiro[indoline-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]trione library.

Ramin Ghahremanzadeh1, Maryam Sayyafi, Somayeh Ahadi, Ayoob Bazgir.   

Abstract

A one-pot method for the efficient and simple synthesis of the novel spiro[indoline-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]trione derivatives by a three-component condensation reaction of barbituric acids, 1H-pyrazol-5-amines and isatins in aqueous media is reported.

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Year:  2009        PMID： 19425616     DOI： 10.1021/cc8001958

Source DB:  PubMed          Journal:  J Comb Chem        ISSN： 1520-4766


  5 in total

Review 1.  Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

Authors:  Roland E Dolle; Bertrand Le Bourdonnec; Karin Worm; Guillermo A Morales; Craig J Thomas; Wei Zhang
Journal:  J Comb Chem       Date:  2010-10-05

Review 2.  Molecular diversity of spirooxindoles. Synthesis and biological activity.

Authors:  Tetyana L Pavlovska; Ruslan Gr Redkin; Victoria V Lipson; Dmytro V Atamanuk
Journal:  Mol Divers       Date:  2015-09-29       Impact factor: 2.943

3.  New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres.

Authors:  Mohamed I Attia; Wagdy M Eldehna; Samar A Afifi; Adam B Keeton; Gary A Piazza; Hatem A Abdel-Aziz
Journal:  PLoS One       Date:  2017-07-25       Impact factor: 3.240

4.  Grindstone Chemistry: Design, One-Pot Synthesis, and Promising Anticancer Activity of Spiro[acridine-9,2'-indoline]-1,3,8-trione Derivatives against the MCF-7 Cancer Cell Line.

Authors:  Perumal Gobinath; Ponnusamy Packialakshmi; Ali Daoud; Saud Alarifi; Akbar Idhayadhulla; Surendrakumar Radhakrishnan
Journal:  Molecules       Date:  2020-12-11       Impact factor: 4.411

5.  Synthesis of spiro[dihydropyridine-oxindoles] via three-component reaction of arylamine, isatin and cyclopentane-1,3-dione.

Authors:  Yan Sun; Jing Sun; Chao-Guo Yan
Journal:  Beilstein J Org Chem       Date:  2013-01-03       Impact factor: 2.883
  5 in total

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