Literature DB >> 19423197

Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents.

B Jayashankar1, K M Lokanath Rai, N Baskaran, H S Sathish.   

Abstract

A series of novel ether-linked bis(heterocycle)s have been synthesized via [3+2]-cycloaddition reaction of nitrile oxide with allyl alcohol followed by intramolecular 1,3-diploar cycloaddition reaction of nitrile imine with carbonyl group. All the newly synthesized compounds were screened for their anti-inflammatory and analgesic activities. Among the list of compounds (7a-k) studied, 7d, 7g, 7j, and 7k exhibited excellent activity comparable to ibuprofen and aspirin at the similar dosages.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19423197     DOI： 10.1016/j.ejmech.2009.04.006

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  10 in total

1.  Synthesis, characterization and bioactivity studies of novel 1,3,4-oxadiazole small molecule that targets basic phospholipase A2 from Vipera russelli.

Authors:  Vivek Hamse Kameshwar; Kumar J R; Babu S Priya; S Nanjunda Swamy
Journal:  Mol Cell Biochem       Date:  2016-12-07       Impact factor: 3.396

2.  1-[(E)-(3,4-Dimethyl-isoxazol-5-yl)imino-meth-yl]-2-naphthol.

Authors:  Hoong-Kun Fun; Madhukar Hemamalini; Abdullah M Asiri; Salman A Khan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-04-10

3.  Synthesis and antimicrobial activity of new 5-(2-thienyl)-1,2,4-triazoles and 5-(2-thienyl)-1,3,4-oxadiazoles and related derivatives.

Authors:  Mohamed A Al-Omar
Journal:  Molecules       Date:  2010-01-22       Impact factor: 4.411

4.  Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles.

Authors:  N C Desai; Nayan Bhatt; Hardik Somani; Amit Trivedi
Journal:  Eur J Med Chem       Date:  2013-06-19       Impact factor: 6.514

5.  Synthesis, antitumor, antibacterial and urease inhibitory evaluation of new piperazinyl N-4 carbamoyl functionalized ciprofloxacin derivatives.

Authors:  Mohamed A A Abdel-Aal; Montaser Sh A Shaykoon; Gamal El-Din A A Abuo-Rahma; Mamdouh F A Mohamed; Mohamed Badr; Salah A Abdel-Aziz
Journal:  Pharmacol Rep       Date:  2021-01-03       Impact factor: 3.024

Review 6.  Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives.

Authors:  Teresa Glomb; Piotr Świątek
Journal:  Int J Mol Sci       Date:  2021-06-29       Impact factor: 5.923

7.  Synthesis, characterization, and in vitro anticancer evaluation of novel 2,5-disubstituted 1,3,4-oxadiazole analogue.

Authors:  Avijit Mazumder; Mohammad Shaharyar
Journal:  Biomed Res Int       Date:  2014-08-10       Impact factor: 3.411

8.  Antinociceptive Activity of Chemical Components of Essential Oils That Involves Docking Studies: A Review.

Authors:  Davidson Barbosa Assis; Humberto de Carvalho Aragão Neto; Diogo Vilar da Fonsêca; Humberto Hugo Nunes de Andrade; Renan Marinho Braga; Nader Badr; Mayara Dos Santos Maia; Ricardo Dias Castro; Luciana Scotti; Marcus Tullius Scotti; Reinaldo Nóbrega de Almeida
Journal:  Front Pharmacol       Date:  2020-05-29       Impact factor: 5.810

Review 9.  Synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles: a review of the literature from 2000-2012.

Authors:  Cledualdo Soares de Oliveira; Bruno Freitas Lira; José Maria Barbosa-Filho; Jorge Gonçalo Fernandez Lorenzo; Petrônio Filgueiras de Athayde-Filho
Journal:  Molecules       Date:  2012-08-27       Impact factor: 4.411

10.  Electrocyclic Ring-Opening of 1,2,4-Oxadiazole[4,5-a]piridinium Chloride: a New Route to 1,2,4-Oxadiazole Dienamino Compounds.

Authors:  Stefano Carella; Misal Giuseppe Memeo; Paolo Quadrelli
Journal:  ChemistryOpen       Date:  2019-09-12       Impact factor: 2.911
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.