Literature DB >> 1942242

Transactivation of human immunodeficiency virus type 1 long terminal repeats by cell surface tumor necrosis factor alpha.

W Tadmori1, D Mondal, I Tadmori, O Prakash.   

Abstract

Tumor necrosis factor alpha (TNF-alpha) is expressed in secreted and cell surface (csTNF-alpha) forms by activated monocytic and T cells. In this report, we demonstrate that csTNF-alpha may predominantly regulate the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) activation in the promonocytic cell line U937 and in the Epstein-Barr virus-transformed B-cell line BH1. Anti-TNF-alpha antibody suppressed both the constitutive expression of the HIV-1 LTR in BH1 cells and the expression induced by phorbol 12-myristate 13-acetate in U937 cells. This suppression was found to be mediated via csTNF-alpha. No correlation between the HIV-1 LTR activation and the secretion of TNF-alpha was evident in these cell lines. Suppression of TNF-alpha secretion by cyclosporin A or by a serine protease inhibitor did not suppress the HIV-1 LTR activation. These observations suggest a novel biological role for csTNF-alpha in the immunopathogenesis of AIDS.

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Year:  1991        PMID： 1942242      PMCID： PMC250679     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  39 in total

1.  Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.

Authors:  S Koenig; H E Gendelman; J M Orenstein; M C Dal Canto; G H Pezeshkpour; M Yungbluth; F Janotta; A Aksamit; M A Martin; A S Fauci
Journal:  Science       Date:  1986-09-05       Impact factor: 47.728

2.  Comparison of in vitro cell cytotoxic assays for tumor necrosis factor.

Authors:  D A Flick; G E Gifford
Journal:  J Immunol Methods       Date:  1984-03-30       Impact factor: 2.303

3.  Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.

Authors:  D Pennica; G E Nedwin; J S Hayflick; P H Seeburg; R Derynck; M A Palladino; W J Kohr; B B Aggarwal; D V Goeddel
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

4.  Morphine-induced transactivation of HIV-1 LTR in human neuroblastoma cells.

Authors:  S P Squinto; D Mondal; A L Block; O Prakash
Journal:  AIDS Res Hum Retroviruses       Date:  1990-10       Impact factor: 2.205

5.  Tumor necrosis factor production by human monocytes is a regulated event: induction of TNF-alpha-mediated cellular cytotoxicity by endotoxin.

Authors:  R S Kornbluth; T S Edgington
Journal:  J Immunol       Date:  1986-10-15       Impact factor: 5.422

6.  Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines.

Authors:  L Montagnier; J Gruest; S Chamaret; C Dauguet; C Axler; D Guétard; M T Nugeyre; F Barré-Sinoussi; J C Chermann; J B Brunet
Journal:  Science       Date:  1984-07-06       Impact factor: 47.728

7.  Tumor necrosis factor (TNF).

Authors:  L J Old
Journal:  Science       Date:  1985-11-08       Impact factor: 47.728

8.  Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272

9.  Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

Authors:  T Decker; M L Lohmann-Matthes; G E Gifford
Journal:  J Immunol       Date:  1987-02-01       Impact factor: 5.422

10.  Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

Authors:  J L Urban; H M Shepard; J L Rothstein; B J Sugarman; H Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205
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  7 in total

Review 1.  Human endogenous retroviruses: nature, occurrence, and clinical implications in human disease.

Authors:  H B Urnovitz; W H Murphy
Journal:  Clin Microbiol Rev       Date:  1996-01       Impact factor: 26.132

2.  Soluble tumor necrosis factor receptor: inhibition of human immunodeficiency virus activation.

Authors:  O M Howard; K A Clouse; C Smith; R G Goodwin; W L Farrar
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

3.  Interleukin 1 induces HIV-1 expression in chronically infected U1 cells: blockade by interleukin 1 receptor antagonist and tumor necrosis factor binding protein type 1.

Authors:  E V Granowitz; B M Saget; M Z Wang; C A Dinarello; P R Skolnik
Journal:  Mol Med       Date:  1995-09       Impact factor: 6.354

4.  Tumour necrosis factor (TNF) and TNF-related molecules in HIV-1+ individuals: relationship with in vitro Th1/Th2-type response.

Authors:  G P Rizzardi; J B Marriott; S Cookson; A Lazzarin; A G Dalgleish; W Barcellini
Journal:  Clin Exp Immunol       Date:  1998-10       Impact factor: 4.330

5.  Impairment of beta chemokine and cytokine production in patients with HIV related Pneumocystis jerovici pneumonia.

Authors:  D Israël-Biet; H Esvant; A M Laval; J Cadranel
Journal:  Thorax       Date:  2004-03       Impact factor: 9.139

6.  Effect of cyclosporin A on inflammatory cytokine production by U937 monocyte-like cells.

Authors:  J E Garcia; M R de Cabo; F M Rodríguez; J P Losada; A J López; J L Arellano
Journal:  Mediators Inflamm       Date:  2000       Impact factor: 4.711

7.  Type I interferon induces inhibitory 16-kD CCAAT/ enhancer binding protein (C/EBP)beta, repressing the HIV-1 long terminal repeat in macrophages: pulmonary tuberculosis alters C/EBP expression, enhancing HIV-1 replication.

Authors:  Y Honda; L Rogers; K Nakata; B Y Zhao; R Pine; Y Nakai; K Kurosu; W N Rom; M Weiden
Journal:  J Exp Med       Date:  1998-10-05       Impact factor: 14.307
  7 in total

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