Literature DB >> 19422092

How can we improve the translational landscape for a faster cure of type 1 diabetes?

Matthias von Herrath1, Andrew Chan.   

Abstract

Translation of novel therapies for type 1 diabetes and other autoimmune diseases to the clinic has been slow despite significant new initiatives from funding agencies. One reason for this is that different incentives drive industry, academia, and funding bodies. These communities therefore lack common goals and often communicate poorly, resulting in unintended obstacles that hamper progress in efficiently translating basic scientific discoveries into medical practice. Here, based on our own personal experiences, we discuss some of the drivers within each community that cause these problems, existing mechanisms to facilitate the translation of science into medical practice, and remaining issues that need to be solved.

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Year:  2009        PMID: 19422092      PMCID: PMC2673858          DOI: 10.1172/jci37593

Source DB:  PubMed          Journal:  J Clin Invest        ISSN: 0021-9738            Impact factor:   14.808


  6 in total

1.  The price of innovation: new estimates of drug development costs.

Authors:  Joseph A DiMasi; Ronald W Hansen; Henry G Grabowski
Journal:  J Health Econ       Date:  2003-03       Impact factor: 3.883

2.  Immunosuppressive drugs and the risk of cancer after organ transplantation.

Authors:  Jacques Dantal; Jean-Paul Soulillou
Journal:  N Engl J Med       Date:  2005-03-31       Impact factor: 91.245

3.  Passing the baton--to whom?

Authors:  Aldo A Rossini
Journal:  J Clin Invest       Date:  2007-02       Impact factor: 14.808

4.  Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs.

Authors:  Damien Bresson; Lisa Togher; Evelyn Rodrigo; Yali Chen; Jeffrey A Bluestone; Kevan C Herold; Matthias von Herrath
Journal:  J Clin Invest       Date:  2006-04-20       Impact factor: 14.808

5.  The Innovative Medicines Initiative (IMI): a new opportunity for scientific collaboration between academia and industry at the European level.

Authors:  N Kamel; C Compton; R Middelveld; T Higenbottam; S-E Dahlén
Journal:  Eur Respir J       Date:  2008-05       Impact factor: 16.671

6.  Tolerance and chimerism after renal and hematopoietic-cell transplantation.

Authors:  John D Scandling; Stephan Busque; Sussan Dejbakhsh-Jones; Claudia Benike; Maria T Millan; Judith A Shizuru; Richard T Hoppe; Robert Lowsky; Edgar G Engleman; Samuel Strober
Journal:  N Engl J Med       Date:  2008-01-24       Impact factor: 91.245

  6 in total
  4 in total

1.  Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group.

Authors:  J B Matthews; T P Staeva; P L Bernstein; M Peakman; M von Herrath
Journal:  Clin Exp Immunol       Date:  2010-05       Impact factor: 4.330

Review 2.  Beta-cell imaging: call for evidence-based and scientific approach.

Authors:  Björn A Blomberg; Ion Codreanu; Gang Cheng; Thomas J Werner; Abass Alavi
Journal:  Mol Imaging Biol       Date:  2013-04       Impact factor: 3.488

3.  2α-Methyl-19-nor-(20S)-1,25-dihydroxyvitamin D(3) protects the insulin 2 knockout non-obese diabetic mouse from developing type 1 diabetes without hypercalcaemia.

Authors:  C M Kiekhaefer; B Weber; M Huggins; C Gorichanaz; J A Nehring; H F DeLuca
Journal:  Clin Exp Immunol       Date:  2011-12       Impact factor: 4.330

4.  Unraveling the autoimmune translational research process layer by layer.

Authors:  Richard S Blumberg; Bonnie Dittel; David Hafler; Matthias von Herrath; Frank O Nestle
Journal:  Nat Med       Date:  2012-01-06       Impact factor: 53.440

  4 in total

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