Literature DB >> 19422010

[18F]SiFA-isothiocyanate: a new highly effective radioactive labeling agent for lysine-containing proteins.

Pedro Rosa-Neto1, Björn Wängler, Ljuba Iovkova, Guido Boening, Andrew Reader, Klaus Jurkschat, Esther Schirrmacher.   

Abstract

A highly efficient (18)F-labeling synthon for universal protein labeling is reported. Diverse (18)F-labeled proteins of 66-144 kDa were prepared with [(18)F]SiFA-isothiocyanate synthesized by an isotopic (19)F for (18)F exchange at the silicon atom. Overall preparative radiochemical yields were 20-40 % after 40-50 min. No bone uptake of (18)F radioactivity was detected until 90 min post-injection of (18)F-SiFA-RSA; this demonstrates the metabolic stability of the [(18)F]SiFA moiety.

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Year:  2009        PMID： 19422010     DOI： 10.1002/cbic.200900132

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  10 in total

1.  The radiolabeling of proteins by the [18F]AlF method.

Authors:  William J McBride; Christopher A D'Souza; Robert M Sharkey; David M Goldenberg
Journal:  Appl Radiat Isot       Date:  2011-08-23       Impact factor: 1.513

2.  Xanthopsin-Like Systems via Site-Specific Click-Functionalization of a Retinoic Acid Binding Protein.

Authors:  Giusy Tassone; Marco Paolino; Cecilia Pozzi; Annalisa Reale; Laura Salvini; Gianluca Giorgi; Maurizio Orlandini; Federico Galvagni; Stefano Mangani; Xuchun Yang; Benedetta Carlotti; Fausto Ortica; Loredana Latterini; Massimo Olivucci; Andrea Cappelli
Journal:  Chembiochem       Date:  2021-11-05       Impact factor: 3.164

3.  Imaging integrin alpha-v-beta-3 expression in tumors with an 18F-labeled dimeric RGD peptide.

Authors:  Ingrid Dijkgraaf; Samantha Y A Terry; William J McBride; David M Goldenberg; Peter Laverman; Gerben M Franssen; Wim J G Oyen; Otto C Boerman
Journal:  Contrast Media Mol Imaging       Date:  2013 May-Jun       Impact factor: 3.161

4.  Isothiocyanate-Functionalized Bifunctional Chelates and fac-[M(I)(CO)3](+) (M = Re, (99m)Tc) Complexes for Targeting uPAR in Prostate Cancer.

Authors:  Benjamin B Kasten; Xiaowei Ma; Kai Cheng; Lihong Bu; Winston S Slocumb; Thomas R Hayes; Steven Trabue; Zhen Cheng; Paul D Benny
Journal:  Bioconjug Chem       Date:  2015-12-30       Impact factor: 4.774

Review 5.  PET designated flouride-18 production and chemistry.

Authors:  Orit Jacobson; Xiaoyuan Chen
Journal:  Curr Top Med Chem       Date:  2010       Impact factor: 3.295

Review 6.  ¹⁸F-labeled silicon-based fluoride acceptors: potential opportunities for novel positron emitting radiopharmaceuticals.

Authors:  Vadim Bernard-Gauthier; Carmen Wängler; Esther Schirrmacher; Alexey Kostikov; Klaus Jurkschat; Bjoern Wängler; Ralf Schirrmacher
Journal:  Biomed Res Int       Date:  2014-07-24       Impact factor: 3.411

7.  t-Bu2SiF-derivatized D2-receptor ligands: the first SiFA-containing small molecule radiotracers for target-specific PET-imaging.

Authors:  Ljuba Iovkova-Berends; Carmen Wängler; Thomas Zöller; Georg Höfner; Klaus Theodor Wanner; Christian Rensch; Peter Bartenstein; Alexey Kostikov; Ralf Schirrmacher; Klaus Jurkschat; Björn Wängler
Journal:  Molecules       Date:  2011-09-02       Impact factor: 4.411

Review 8.  Reaction of [18F]Fluoride at Heteroatoms and Metals for Imaging of Peptides and Proteins by Positron Emission Tomography.

Authors:  Kymberley R Scroggie; Michael V Perkins; Justin M Chalker
Journal:  Front Chem       Date:  2021-06-23       Impact factor: 5.221

9.  Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon.

Authors:  Jan Bucerius; Ingrid Dijkgraaf; Felix M Mottaghy; Leon J Schurgers
Journal:  Eur J Nucl Med Mol Imaging       Date:  2018-10-09       Impact factor: 9.236

10.  Evaluation of Organo [18F]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers.

Authors:  Sofia Otaru; Surachet Imlimthan; Mirkka Sarparanta; Kerttuli Helariutta; Kristiina Wähälä; Anu J Airaksinen
Journal:  Molecules       Date:  2020-03-07       Impact factor: 4.411
  10 in total

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