| Literature DB >> 19419865 |
Motoi Nakahara1, Takeshi Kuboyama, Akihiro Izawa, Yoshiyuki Hari, Takeshi Imanishi, Satoshi Obika.
Abstract
Oligonucleotides including C-nucleotides having 1-substitued 1H-1,2,3-triazoles as artificial nucleobases were conveniently synthesized by the post-elongation modification method using the copper(I)-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC) reaction. The base-pairing properties of the triazole nucleobase analogs in forming duplexes with oligonucleotides were investigated by the T(m) experiments.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19419865 DOI： 10.1016/j.bmcl.2009.04.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823