Literature DB >> 27296353

Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores.

Dominik K Kölmel1, Luzi J Barandun1, Eric T Kool1.   

Abstract

A facile and general procedure for the preparation of alkynyl C-nucleosides with varied fluorophores is presented. Sonogashira coupling was used as a key reaction to conjugate the dyes to an easily accessible ethynyl functionalized deoxyribose derivative. The new C-nucleosides were used for the preparation of DNA-based polyfluorophores.

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Year:  2016        PMID： 27296353      PMCID： PMC4935563          DOI： 10.1039/c6ob01199c

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  40 in total

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5.  Studies on the generation of unnatural C-nucleosides with 1-alkynyl-2-deoxy-D-riboses.

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Journal:  Bioconjug Chem       Date:  2009-12       Impact factor: 4.774

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Review 10.  Synthesis of DNA/RNA and their analogs via phosphoramidite and H-phosphonate chemistries.

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Journal:  Molecules       Date:  2013-11-18       Impact factor: 4.411
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